临床特征和并发症的发展在成人发病和儿童-青少年发病的1型糖尿病之间有所不同:来自土耳其高等医疗中心的一份报告
Ramazan Çakmak1,2, Özge Telci Çaklılı2, Ayşe Merve Ok2
1Department of Internal Medicine and Division of Endocrinology and Metabolic Diseases, Istanbul Health and Technology University, Istanbul, Türkiye.
Journal of diabetes research
|April 17, 2025
概括
成人发病的1型糖尿病 (T1DM) 与儿童发病的T1DM呈现不同,超重和脂质失调的风险更高. 低初始C-水平预测T1DM患者未来的微血管和宏血管并发症.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 临床研究 临床研究
背景情况:
- 发病时的年龄是1型糖尿病 (T1DM) 异质性的关键因素.
- 了解儿童和青少年发病的T1DM与成人发病的T1DM之间的差异对于管理至关重要.
- 预测并发症需要根据发病年龄确定不同的危险因素.
研究的目的:
- 确定儿童和青少年发病的T1DM与成人发病的T1DM之间的临床和实验室区别.
- 确定T1DM中微血管和宏血管并发症的预测因子.
- 根据T1DM诊断时的年龄来比较表现和随访特征.
主要方法:
- 从2000年1月到2019年12月,对490名T1DM患者进行了回顾性观察性研究.
- 评估临床表现,实验室值和并发症的发展.
- 多变量分析和卡普兰-梅尔生存分析,以确定并发症的预测因素.
主要成果:
- 成人发病的T1DM显示出较高的基线C-和GADA患病率,但较低的酸酶呈现.
- 成人发病的T1DM在随访期间增加了超重/肥胖和失脂血症/高脂血症的风险.
- 低初始C- (<0.383 ng/mL) 预测了未来的微血管和宏血管并发症,而不依赖于发病时的年龄.
结论:
- 临床表现和预后在成人发病的T1DM和儿童-青少年发病的T1DM之间显著不同.
- 最初的C-水平是长期T1DM并发症的关键预测因素.
- 早期识别低C可能会指导T1DM患者的积极管理策略.
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