用对比增强的超声波来评估质量在现场正常热机器 perfusion 期间
Samuel J Tingle1,2,3, Chloe Connelly1, Emily K Glover1,2,4
1Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
概括
与对比度增强的超声波 (CEUS) 客观地评估在正常热机器输液 (NMP) 期间的脏微血管输液. 这种方法可以预测的活力,为在移植之前评估捐赠器官提供了一个潜在的工具.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 医疗成像医学成像
- 移植科学 移植科学
背景情况:
- 在评估捐赠的活力方面,正常热机器输液 (NMP) 是至关重要的.
- 评估微血管输液是关键的,因为减少的流量是缺血介导的急性损伤的基础.
- 与对比度增强的超声波 (CEUS) 提供了一种在NMP期间客观微血管评估的潜在方法.
研究的目的:
- 评估CEUS在NMP期间在猪和人类脏中量化微血管输液的实用性.
- 为了将CEUS发现与损伤和亡的生物标志物相关联.
- 开发用于定量CEUS分析的工具.
主要方法:
- 基于血液的NMP在猪和人类脏上进行.
- 通过对比玻尿酸注入NMP动脉肢体,CEUS进行了注射.
- 量化了微血管输液,并使用z-score正常化得出了CEUS得分.
主要成果:
- 在猪脏中,微血管输液不良与尿中NGAL和DNA碎片化增加相关.
- 在人类脏中,2小时的CEUS得分与组织学DNA碎片化有很强的相关性 (r = -0.937) 并预测了24小时的尿液NGAL (r = -0.925).
- 整体血流与这些损伤标志物没有相关性.
结论:
- 在脏NMP期间,CEUS提供客观的,医疗点微血管输液评估.
- 早期的CEUS得分显示了后来的损伤标志物的预测价值.
- 在专注于器官康复和移植的中心,CEUS是评估质量的有希望的工具.
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