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一个机器学习模型用于预测短期授精后使用胚胎图像预测受精

Masato Saito^1,2, Hirofumi Haraguchi¹, Ikumi Nakajima¹

¹Matsumoto Ladies IVF Clinic Tokyo Japan.

Reproductive medicine and biology

|April 17, 2025

概括

一个机器学习模型 (MLM) 从胚胎图像准确地预测受精,与专家胚胎学家相匹配. 这种人工智能工具有助于早期拯救ICSI决策,并改善患者的治疗结果.

科学领域:

生殖医学生殖医学
医疗保健中的人工智能
胚胎学胚胎学

背景情况:

早期预测受精对于及时干预辅助生殖技术至关重要.
胚胎学家对受精的手动评估可能是主观的,耗时的.
机器学习为客观和高效的胚胎评估提供了一个潜在的解决方案.

研究的目的:

开发和评估一种机器学习模型 (MLM),用于使用胚胎图像预测受精后的受精.
为了比较MLM的预测性能与胚胎学家的手动分类.
评估MLM对于早期救援的实用性内细胞质精子注射 (ICSI).

主要方法:

胚胎图像是在输精后4.5小时和8小时获得的.
ResNet50用于图像预处理和矢量提取.
轻度梯度增强机 (轻度GBM) 用于模型训练.
受精预测被MLM评估,并与高级和初级胚胎学家的分类进行了比较.

主要成果:

微型胚胎测试的准确度为0.71±0.01,超过了初级胚胎学家 (0.61±0.05).
在MLM和高级胚胎学家之间没有发现显著差异 (准确率为0.75±0.05).
对于回忆,F1得分和曲线下的面积,观察到类似的趋势,MLM的表现与高级胚胎学家相比.

结论:

开发的MLM通过分析胚胎图像中的微妙细胞质变化,有效地预测受精.
该模型显示了在早期救援ICSI程序中增强临床决策的潜力.
整合像这种MLM这样的AI工具可以在生育治疗中改善患者的结果.

关键词:

细胞质细胞质.早期救援 ICSI ICSI 的情况这是受精,受精,受精.机器学习是机器学习.短期授精是短时间的授精.

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