挽救肺 SBRT 可能是一个可治愈的选择后的叶片切除术
Geovanne Pedro Mauro1, Maria Luiza Alves José Ferioli Pereira2, Mauricio José de Oliveira Costa3
1Radiology and Oncology, University of Sao Paulo Hospital of Clinics, Sao Paulo, Brazil.
概括
立体体射线疗法 (SBRT) 是手术后肺癌的可行和安全的救援治疗方法,其结果与初级SBRT相似. 这种方法为需要进一步治疗的患者提供了可行的选择.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 胸部外科手术 胸部外科手术
背景情况:
- 立体性身体放射疗法 (SBRT) 是一种针对早期非小细胞肺癌 (NSCLC) 的成熟治疗方法.
- 主要手术后的救生SBRT是复发或残留疾病的新兴策略.
- 将SBRT作为主要模式与救援治疗进行比较对于治疗优化至关重要.
研究的目的:
- 评估SBRT作为肺癌术后救援治疗的可行性和结果.
- 为了将这些结果与SBRT作为NSCLC的初始治疗方法进行比较.
- 在现实世界患者队列中评估救援SBRT的安全性和有效性.
主要方法:
- 在2017年1月至2022年1月期间接受SBRT治疗的早期NSCLC患者的回顾性分析.
- 患者被分为初级SBRT和救援SBRT组.
- 分析了包括整体存活率,局部控制和毒性在内的临床结果.
主要成果:
- 分析了68名患者,10%的患者在之前的手术后接受了救援SBRT.
- 救援SBRT主要治疗中心病变,而初级SBRT则专注于外围病变.
- 总生存率和局部控制率在各组之间是可比的 (2年生存率:73.5%).
- 晚期3-4级肺炎发生在8.2%的患者中,主要是在初级SBRT组中.
结论:
- 作为一次性肺癌手术后的救援治疗,SBRT是可行的,并显示出可接受的安全性.
- 救援SBRT的瘤结果似乎与初级SBRT取得的结果相当.
- 拯救性SBRT代表了一种可行的治疗选择,选择的患者曾经接受过之前的手术.
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