大麻素作为多向药物用于治疗眼的自身免疫性
Lakshmi Pk1, Rajesh Singh Pawar2, Yogesh Kumar Katare3
1Dept. of Pharmacognosy, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Ponekkara, Kochi - 682041, India.
ACS pharmacology & translational science
|April 17, 2025
概括
大麻素通过向自身免疫和神经退行症来治疗眼,显示出有前途的潜力. 这种多目标的方法可能有利于患有常态紧张性玻璃眼的患者,解决视力丧失和RGC死亡.
科学领域:
- 眼科医生 眼科 眼科
- 神经免疫学 神经免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 玻璃眼,不可逆转的视力丧失的主要原因,涉及视网膜质细胞 (RGCs) 的神经退行.
- 自免疫性越来越被认为是RGC死亡和青光眼病因的关键因素.
- 目前的治疗方法主要是控制眼内压力 (IOP),往往无法阻止神经退行,特别是在常态紧张型玻璃眼中.
研究的目的:
- 探索大麻素作为一种多目标治疗方法的潜力.
- 调查大麻素在解决自身免疫,神经炎症和青光眼神经保护方面的作用.
- 强调大麻素在治疗青光眼的相关性,特别是在正在进行的RGC退行症的正常血压患者中.
主要方法:
- 对眼,自身免疫和大麻素药理学现有文献的综述.
- 对大麻素机制的分析,包括神经保护,抗炎和免疫抑制作用.
- 对肠-视网膜轴和Wnt信号通路的检查,与玻璃眼和大麻素作用相关.
主要成果:
- 大麻素具有有利于眼的多方面的特性,包括IOP降低,神经保护和抗炎作用.
- 大麻素调节免疫反应,并对参与自身免疫的免疫细胞表现出表观遗传作用.
- 有证据表明,大麻素可以准多个涉及到眼神经退行症的途径.
结论:
- 大麻素代表了一种有前途的多目标方法来治疗青光眼,特别是在自身免疫相关的神经退行症.
- 这一策略可能为经历无声RGC损失的正常血压绿内障患者提供新的治疗途径.
- 进一步研究基于大麻素的疗法可以通过解决其复杂的病因来彻底改变绿眼的治疗方法.
相关概念视频
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...