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Updated: May 11, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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由蛋白质酶抑制剂积累的过度激活诱导的cytidine deaminase在激活的B细胞样扩散大B细胞淋巴瘤中拯救了异常的类切换

Zhuangwei Lv1,2, Chen Xu3, Zhenzhen Wang4,5

  • 1Department of Laboratory Medicine, Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.

Experimental and therapeutic medicine
|April 17, 2025
PubMed
概括

蛋白质酶抑制剂MG132通过恢复异常的B细胞抗体类切换重组 (CSR) 来阻止淋巴瘤的生长. MG132增加了激活诱导的细胞氨酸脱氨酶 (AID) 水平,纠正激活B细胞样扩散大B细胞淋巴瘤 (ABC-DLBCL) 中的CSR缺陷.

关键词:
MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132 MG132激活的类似B细胞的扩散大B细胞淋巴瘤.激活诱导的cytidine 脱氨酶.类开关重组组合类开关重组蛋白酶体抑制剂是一种蛋白酶体抑制剂.无处不在的化

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