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孤立的头骨神经障碍作为多发性硬化症的征兆:视神经与"其他"相比

Arianna Di Stadio^1,2, Pietro Scribani Rossi³, Diego Kaski⁴

¹Department of Mental and Physical Health and Preventive Medicine, Otolaryngology Unit, University of Campania "Luigi Vanvitelli", Napoli, Campania, Italy.

Frontiers in neurology

|April 17, 2025

概括

多发性硬化症 (MS) 其他头骨神经 (OCN) 干扰的初始症状,而不是视神经炎 (ON),与4年内更少的复发和较轻的残疾有关.

科学领域:

神经学神经学
神经免疫学神经免疫学
临床神经科学临床神经科学

背景情况:

神经参与多发性硬化症 (MS) 是常见的,但它的预后意义是有争议的.
以前的猜测表明,最初的MS表现涉及神经,不包括视神经炎,可能表明疾病的进展较轻.

研究的目的:

为了比较患有初始视神经炎 (ON) 的MS患者的4年临床结果与其他神经 (OCN) 参与.
调查初始的OCN症状是否与ON相比预测了不同的疾病进展.

主要方法:

通过经过修订的麦当劳标准诊断的84名以前没有接受过治疗的多发性硬化症患者的追溯分析.
纳入标准:第一个暗示ON或OCN的症状,定期的临床/放射学随访,没有并发症.
评估结果:复发次数和扩展残疾状况量表 (EDSS) 4 年的得分. 统计分析包括回归模型和赔率比率.

主要成果:

55名患者呈现了ON,29名患者呈现了OCN (例如,双眼视,三角骨疼痛,听力/前体症状).
患有ON的患者较年轻 (p=0.02).
与OCN组相比,ON组在4年内出现更高的复发风险 (OR:1.53) 和更大的残疾进展 (OR:1.60).

结论:

与OCN参与的MS发病与较少的复发和更好的EDSS得分在4年的随访与ON发病相比.
这些发现表明,最初的OCN参与可能表明多发性硬化症疾病过程更有利.

关键词:

头骨神经神经神经面部麻面部麻多发性硬化症多发性硬化症视神经的视觉神经是如何工作的视神经炎是一种视神经炎.三股骨头疼痛三股骨头疼痛

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