C-反应蛋白-白蛋白-淋巴细胞指数和中风之间的关联:NHANES分析 (1999-2010)
Yizhou Chen1, Meifang Liu2,3, Yi Zhang4
1Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan, China.
Frontiers in neurology
|April 17, 2025
概括
较低的CALLY指数可能会增加中风风险. CALLY指数比SIRI和SII更好地预测中风,为未来的中风预防策略提供了洞察力.
科学领域:
- 心血管流行病学心血管流行病学
- 生物标志物研究的研究.
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,中风仍然是导致残疾和死亡的主要原因.
- 确定可靠的生物标志物来预测中风风险对于有效的预防至关重要.
- 卡利指数是一种新的生物标志物,需要对其与中风相关性进行研究.
研究的目的:
- 研究美国人口中CALLY指数和中风风险之间的关系.
- 评估CALLY指数对中风的预测性能.
- 将CALLY指数的预测效率与其他已建立的指数 (如SIRI和SII) 进行比较.
主要方法:
- 使用NHANES (1999-2010) 数据对17511名参与者的横截面研究.
- 对CALLY指数和自我报告中风状态的实验室标记的分析.
- 应用多变量逻辑回归,子组分析,受限立方 (RCS) 和接收器操作特征 (ROC) 分析.
主要成果:
- 在CALLY指数和中风风险之间观察到非线性,L形负相关性.
- 较高的CALLY指数水平与降低中风风险显著相关 (OR=0.99,p=0.045).
- CALLY指数的最高四分位数显示,中风的可能性降低了25% (OR=0.75,p=0.030) 和优异的预测性能比SIRI和SII.
结论:
- 降低的CALLY指数可能表明中风风险增加.
- 与SIRI和SII相比,CALLY指数显示了对中风风险的优越预测能力.
- 这些发现支持CALLY指数在中风风险评估和预防策略中的潜在实用性.
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