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在口服液状平原中表达了表皮-半机体转变相关蛋白质Claudin-10的表达

Evangelos Parcharidis¹, Dimitrios Andreadis¹, Elizabeth Lazaridou²

¹Department of Oral Medicine and Oral Pathology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, GRC.

|April 17, 2025

概括

克劳丁-10的表达在口腔平坦 (OLP) 中发生变化,这是一个常见的口腔粘膜状况. 这项研究在OLP组织中分析了Claudin-10,揭示了与正常组织相比,其上皮和树皮分布的显著变化.

科学领域:

口腔病理学口腔病理学
皮质 - 介质细胞过渡 (EMT)
免疫组织化学免疫组织化学

背景情况:

口腔平坦 (OLP) 是一种普遍存在的口腔粘膜状况,原因不明.
表皮-介质细胞转换 (EMT) 是发育和疾病 (包括癌症) 中的一个关键过程.
克劳丁-10,一种与EMT相关的蛋白质,由CLDN10基因编码.

研究的目的:

为了研究口腔平坦菌 (OLP) 中Claudin-10的免疫组织表达.
为了将OLP组织中的Claudin-10表达与正常口腔粘膜进行比较.

主要方法:

在51个OLP组织样本和10个正常口腔粘膜样本上进行了免疫组织化学染色.
分析的重点是口腔上皮层和腹膜的不同层中Claudin-10的表达水平.

主要成果:

与对照组相比,OLP上皮质中的克劳丁-10表达显著上调 (p<0.001).
表面上皮质和侧膜在OLP中显示出明显更高的Claudin-10染色 (分别为p=0.008和p=0.027).
中间和基底上皮层在OLP中显著减少了Claudin-10表达 (分别为p=0.001和p<0.001).

结论:

这是第一个分析口腔粘膜疾病中的Claudin-10表达的研究.
克劳丁-10的表达在口腔平坦中失调.
研究结果表明,在OLP中涉及Claudin-10的表皮和底层组织之间存在潜在的相互作用.

关键词:

克劳丁 - 10 克劳丁 - 10 克劳丁皮质转化为介质酶的过渡.免疫组织化学免疫组织化学口腔疾病是一种口腔疾病.在口腔中,有平坦的海.

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