肝细胞癌中的免疫微环境和免疫疗法:机制和进展
Dong Xie1, Yang Liu2, Fangbiao Xu3
1Diagnosis and Treatment Center for Digestive Diseases of Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, China.
Frontiers in immunology
|April 17, 2025
概括
肝细胞癌 (HCC) 的进展是由瘤微环境 (TME) 驱动的. 免疫检查点抑制剂 (ICI) 等免疫疗法在通过调节TME内的免疫细胞来治疗HCC方面表现有前途.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 肝细胞癌 (HCC) 是全球癌症死亡的主要原因.
- 瘤微环境 (TME) 通过复杂的细胞相互作用显著影响HCC的进展.
- 在TME内的关键免疫细胞,包括巨细胞,淋巴细胞和树突细胞,在免疫逃避中至关重要.
研究的目的:
- 审查免疫微环境在HCC中的作用.
- 探索用于HCC管理的免疫治疗策略的治疗潜力.
- 为了突出最近在HCC免疫疗法的进展.
主要方法:
- 关于HCC免疫疗法的最新进展的文献综述.
- 分析免疫细胞在瘤微环境中的作用.
- 综合各种免疫治疗方法及其组合的数据.
主要成果:
- 构成肌体和免疫细胞的TME对HCC的进展和免疫规避至关重要.
- 各种免疫细胞 (TAMs,TILs,CTLs,Tregs,MDSCs,DCs,NK细胞) 在HCC中起着不同的作用.
- 免疫疗法,包括免疫检查点抑制剂 (ICI),癌症疫苗和采用细胞疗法 (ACT),显示出治疗潜力.
- 组合疗法 (例如,双重ICI,ICI与向药物或局部治疗) 在HCC患者中显示出更好的结果.
结论:
- 了解免疫微环境是开发有效HCC治疗的关键.
- 免疫疗法为增强HCC的抗瘤反应提供了有希望的途径.
- 涉及免疫疗法的组合策略对于改善HCC患者的治疗结果至关重要.
更多相关视频
12:24A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
5.0K
11:08Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
Published on: February 14, 2025
590
相关概念视频
01:27Tumor Immunotherapy
400
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
400
01:27Cytotoxic T Cells-mediated Immune Response
726
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
726
02:17The Tumor Microenvironment
6.4K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.4K
01:40Cell-mediated Immune Responses
65.3K
Overview
65.3K
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K