需要抗血栓治疗的血友病患者的管理:加拿大修改的德尔菲共识研究
Kelsey Uminski1,2, Tzu-Fei Wang3,4, Lisa Duffett3,4
1Department of Medicine, Division of Hematology and Hematological Malignancies, University of Calgary, Calgary, AB, Canada.
概括
加拿大专家制定了32项共识建议,用于在血友病 (PWH) 患者中管理抗血栓治疗 (ATT). 这些指导方针解决了这一群体日益增长的安全和有效的ATT战略需求.
科学领域:
- 血液学 血液学 血液学
- 血栓形成的原因之一是血栓形成.
- 临床指南 临床指南
背景情况:
- 血友病 (PWH) 患者的预期寿命增加需要管理并发症.
- 对于PWH来说,越来越需要抗血栓治疗 (ATT),以减轻动脉或静脉血栓风险.
- 目前,有限的证据指导PWH中ATT的临床决策.
研究的目的:
- 为管理需要ATT的PWH制定加拿大共识建议.
- 为在ATT上照顾PWH的临床医生提供基于证据的指导.
主要方法:
- 使用了修改后的Delphi技术.
- 与加拿大血友病专家一起进行文献审查和焦点小组,以告知初步陈述.
- 专家小组成员使用7点的利克特级别对陈述进行评分;共识定义为>70%的同意.
主要成果:
- 来自五个加拿大血友病中心的八名医生参与了这项研究.
- 在32个声明中达成共识,这些声明涵盖了一般护理,风险评估,治疗计划和出血管理.
- 所有陈述在两轮内达成共识,完成了100%.
结论:
- 为了管理需要ATT的PWH,制定了32条基于共识的建议.
- 这些建议解决了临床实践中一个关键的未满足需求.
- 这些指南旨在支持这种患者群体中复杂和不断变化的临床决策.
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