管理对血脂的影响:对实验性人类研究的系统审查和剂量反应元分析
Teresa Urbano1, Lauren A Wise2, Gianluca Fiore1
1Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, Medical School-University of Modena and Reggio Emilia, 41125 Modena, Italy.
Nutrition reviews
|April 17, 2025
概括
每天200微克以上的补充剂可能会对血脂产生不利影响,降低HDL和LDL胆固醇,同时增加甘油三. 这一元分析强调了高摄入对心血管健康的潜在风险.
科学领域:
- 营养生物化学 营养生物化学
- 心血管健康 心血管健康
- 代谢综合征是代谢综合征的一种.
背景情况:
- 是一种必不可少的微量元素,已知与不利的代谢和心血管结果有关.
- 以前的研究表明,过度暴露与高血压和糖尿病等疾病之间存在联系.
- 在人体研究中检查对脂质资料的影响的剂量反应元分析中存在差距.
研究的目的:
- 评估摄入量/血度和血脂变化之间的剂量反应关系.
- 为了研究对总胆固醇,高密度胆固醇,低密度胆固醇和甘油三的作用.
- 用受限立方线回归分析剂量反应曲线.
主要方法:
- 进行了主要科学数据库 (PubMed,科学网,Embase,科克兰图书馆) 的系统搜索.
- 确定了27项涉及成年人的随机对照试验 (RCT),并提取了数据.
- 限制的立方线回归被用于剂量反应分析.
主要成果:
- 摄入200微克/天或更高的剂量降低了HDL和LDL胆固醇,并增加了甘油三.
- 血度超过150μg/L与较高的甘油三和LDL以及较低的HDL相关.
- 无机,更长的干预持续时间 (>3个月) 和欧洲人群摄入量>300μg/天的不良影响更为明显.
结论:
- 在当前上限摄入水平或以上的管理表明对血液脂质有不良影响.
- 一个U形曲线表明,在非常低的摄入量水平下,可能会有好处,但在较高剂量下会有风险.
- 这些发现强调了监测摄入量以预防心血管不良影响的重要性.
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