百合素通过调节P62-自-Keap1/Nrf2通路来保护角膜内皮细胞免受氧化应激
Chunyu Liu1, Jiaqi Shen1, Guozhen Niu1
1Department of Ophthalmology, Tongji Hospital Affiliated with Tongji University, Shanghai 200065, People's Republic of China.
Journal of agricultural and food chemistry
|April 17, 2025
概括
百合素 (LYC) 保护角膜内皮细胞免受氧化应激,并减缓Fuchs.
科学领域:
- 眼科医生 眼科 眼科
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 氧化应激是角膜内皮损伤和相关疾病的主要因素.
- 利科 (LYC) 是一种强大的天然抗氧化剂,在疾病预防方面表现有前途,但其在角膜内皮保护中的作用尚不清楚.
研究的目的:
- 调查烯 (LYC) 对抗氧化应激诱导的角膜内皮损伤的保护作用和潜在机制.
- 在Fuchs内皮角膜缩症 (FECD) 的疾病模型中评估利科的疗效.
主要方法:
- 使用B4G12细胞建立了氧化应激诱导损伤模型.
- 开发了一种针对Fuchs内皮角膜发育不良 (FECD) 的遗传小鼠模型.
- 用烯 (LYC) 治疗了这两种模型,以评估其保护作用.
主要成果:
- 莱科 (LYC) 证明对角膜内皮细胞有显著的保护.
- 在小鼠模型中,LYC治疗有效地减缓了Fuchs内皮角膜缩症 (FECD) 的进展.
- 保护机制涉及P62的上调,自的激活,Keap1降解和Nrf2核转位,导致增强的抗氧化蛋白活性.
结论:
- 莱科 (LYC) 为保护角膜内皮提供了一个潜在的治疗策略.
- 这项研究强调了一种新的非手术方法来管理与角膜内皮损伤相关的疾病,包括Fuchs内皮角膜缩症 (FECD).
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