Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.1K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.1K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

11.3K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.3K
Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

13.7K
For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
13.7K
Autoimmune Disorders01:29

Autoimmune Disorders

319
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
319

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Serum DSDNA is Associated With Psoriasis.

Experimental dermatology·2026
Same author

Global research trends on exosomes in atherosclerosis: a bibliometric and scientometric analysis (2004-2025).

Frontiers in cardiovascular medicine·2026
Same author

Acetyl-CoA acyltransferase 2 palmitoylation drives liver fibrosis by inducing hepatic stellate cell ferroptosis.

Redox biology·2026
Same author

Comment on "Clinical Application of a New Near-Infrared Light-Emitting Diode with Broader Spectrum for Skin Rejuvenation and Hair Growth Enhancement".

Aesthetic plastic surgery·2026
Same author

Comment on 'Antibiotics, analgesics and antifungals are commonly implicated in acute generalized exanthematous pustulosis; a retrospective analysis of 1410 cases': a fresh progress.

Clinical and experimental dermatology·2026
Same author

Rare Natural SNP Activates SHOOT APICAL MERISTEM ENLARGER1 to Increase Branch Number and Silique Number on the Main Inflorescence in Brassica napus.

Plant biotechnology journal·2026

相关实验视频

Updated: May 11, 2025

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

17.3K

关于双链DNA与系统性红斑狼之间相关性的研究.

Qin Qin1,2, Yirui Wang1,2, Sihao Yan1,2

  • 1Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Experimental dermatology
|April 17, 2025
PubMed
概括

在全身性红斑狼 (SLE) 患者中,双链DNA (dsDNA) 的升高水平显示出疾病评估的潜力. 测量血清dDNA可能为SLE提供更简单的诊断和管理工具.

关键词:
这是双链DNA的双链DNA.在外基因组中,外基因组是外基因组.系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.

更多相关视频

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

12.9K
Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
05:28

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

2.0K

相关实验视频

Last Updated: May 11, 2025

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

17.3K
Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

12.9K
Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
05:28

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

2.0K

科学领域:

  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学
  • 类风湿病学 类风湿病学

背景情况:

  • 循环的无细胞DNA (cfDNA) 涉及到系统性红斑狼 (SLE) 病变的发生.
  • 目前的cfDNA检测缺乏SLE的诊断一致性.
  • 双链DNA (dsDNA),cfDNA组成部分在SLE中的作用需要进一步研究.

研究的目的:

  • 调查血清dDNA水平与SLE之间的相关性.
  • 在SLE患者中探索血清dSDNA和外体dSDNA之间的关系.
  • 评估dsDNA作为SLE诊断和疾病进展的生物标志物的潜力.

主要方法:

  • 用光定量方法测量血清dSDNA度.
  • 使用倾向分数匹配 (PSM) 来比较148名SLE患者和444名健康对照.
  • 提取了血液外体细胞以分析血清和外体细胞的DNA相关性.

主要成果:

  • 与健康对照组相比,SLE患者的血清dSDNA水平显著更高.
  • 在SLE患者的血清dSDNA水平与季节和其他临床指标相关.
  • 在血清dSDNA和外体dSDNA之间发现了显著的关联,与dSDNA受体基因的上调.

结论:

  • 血清dSDNA显示出作为评估SLE疾病进展的快速和简单工具的希望.
  • 需要进一步的研究来阐明SLE中升高dsDNA的机制.
  • dsDNA检测可以帮助医生和患者在SLE管理.