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在儿童早期严重的口腔微生物群中,王国间的相互作用和环境的影响
Lingjia Weng1,2,3, Yuqi Cui1,2,3, Wenting Jian1,2,3
1Hospital of Stomatology, SunYat-sen University, Guangzhou, Guangdong, China.
Microbiology spectrum
|April 17, 2025
概括
这项研究表明,患有严重幼儿 (S-ECC) 的儿童的口腔微生物群落发生了变化,特定的细菌和真菌水平增加. 唾液pH,但不是铁或化物,与这些微生物变化有关.
科学领域:
- 微生物学 微生物学
- 儿科牙科 儿科牙科
- 口腔健康 口腔健康
背景情况:
- 牙损是由口腔生态系统内的复杂微生物相互作用造成的.
- 严重的幼儿 (S-ECC) 严重影响儿童的口腔健康和整体福祉.
- 了解S-ECC中的微生物动态对于制定有效的预防策略至关重要.
研究的目的:
- 研究患有S-ECC的儿童的微生物多样性和跨王国相互作用.
- 评估唾液pH和微量元素对S-ECC口腔微生物群落的影响.
- 确定与S-ECC相关的特定细菌和真菌物种.
主要方法:
- 对61名年龄在3至4岁的儿童进行了分析,他们的病状况各不相同.
- 测量唾液的pH值,缓冲能力和微量元素 (铁,化物).
- 16S rRNA和ITS基因测序以表征唾液和斑块中的细菌和真菌群体.
主要成果:
- 患有S-ECC的儿童表现出细菌多样性的减少和菌性物种如*Streptococcus mutans*的丰富性增加.
- 在S-ECC病例中, *Candida albicans* 的流行率更高.
- 铁/含量和微生物组成之间没有发现显著的相关性;然而,特定的种群 (*Veillonella*, *Propionibacterium*, *Candida*) 与减少的唾液pH相关.
结论:
- S-ECC的特点是细菌和真菌群落的特定变化,其中*S. mutans*和*C. albicans*发挥了潜在的作用.
- 唾液pH值是一个关键的环境因素,与S-ECC中的微生物变化有关,挑战铁和的作用.
- 研究结果突出了考虑到微生物相互作用和口腔微环境的有针对性的干预措施的必要性.
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