患者报告的真实世界毒性症状监测对患者,临床医生和指导方针制定者的指导方针和护理的好处和局限性
Y Smit1, L Verweij1, A Currie1
1Department of Hematology, Radboud University Medical Center, Nijmegen, the Netherlands.
Cancer medicine
|April 17, 2025
概括
通过患者报告的数据进行毒性监测的现代化为慢性髓性白血病 (CML) 护理提供了好处. 解决现实世界症状监测的局限性是指导方针整合和改善患者结果的关键.
科学领域:
- 在瘤学瘤学.
- 患者报告的结果
- 临床指南 临床指南
背景情况:
- 毒性监测需要现代化,以纳入真实世界患者报告的数据.
- 利益相关者对将患者报告的毒性症状纳入指南的观点基本上是未知的.
- 这种知识差距阻碍了学习医疗保健系统的发展和日常临床整合.
研究的目的:
- 探索利益相关者的观点,以将现实世界患者报告的毒性症状纳入临床指南.
- 在慢性髓性白血病 (CML) 护理中确定现实世界毒性症状监测的好处和局限性.
- 确定可操作的知识差距,用于CML指导方针的制定.
主要方法:
- 定性研究涉及采访39名CML患者和18名CML临床医生,包括血液学家和指导方针制定者.
- 采访被录音,转录,并使用适应文献的框架编码.
- 一个经过RAND修改的Delphi程序,一个专家小组优先考虑了所识别的知识缺口.
主要成果:
- 确定了31个好处和局限性;新的好处包括系统地纳入患者的症状,个性化咨询,并使用汇总数据填补知识差距.
- 一个专家小组就CML护理中的14个知识差距达成共识,这些知识差距可以通过患者报告的毒性数据来解决.
- 限制集中在适合性,接受性和适用性,担心建立因果关系和增加价值而不是公开讨论.
结论:
- 利用患者报告的毒性监测的好处和解决其局限性对于最大限度地提高价值和吸收至关重要.
- 准则的制定者认为汇总的真实世界毒性数据是有益的.
- 识别的知识差距为推进CML指南的制定提供了具体的目标.
相关概念视频
01:19Pharmacovigilance
742
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
742
01:26Toxic Reactions: Overview
906
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
906
01:26Methods of Documentation II: POMR
847
The Problem-Oriented Medical Record (POMR) revolutionized medical record-keeping by introducing a systematic approach focusing on the patient's problems rather than merely listing symptoms. Dr. Lawrence Weed's introduction of this method in the 1960s marked a significant advancement in medical documentation. The POMR framework consists of four key components: the database, problem list, plan of care, and progress notes.
847
01:30Pulse rhythm
718
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
718
01:12Analysis of Population Pharmacokinetic Data
197
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
197