乳球球菌 (Lactococcus petauri) LZys1调节肠道微生物群,降低叶FXR-FGF15信号传输,并调节肝功能
Ouyang Li1,2, Yingshun Zhou3, Dayoung Kim1,4
1Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China.
Microbiology spectrum
|April 17, 2025
概括
乳球球菌 petauri LZys1,一个潜在的益生菌,改变了小鼠的肠道微生物群和胆酸概况. 这导致通过FXR-FGF15信号通路破坏肝功能,建议谨慎使用益生菌.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 乳球球菌 petauri LZys1 在体外显示了益生菌的潜力.
- 在体内对宿主生理学的影响还不太清楚.
研究的目的:
- 研究口服L. petauri LZys1对小鼠肠道微生物群和肝功能的影响.
- 阐明涉及胆酸代谢和信号通路的潜在机制.
主要方法:
- 在C57BL/6雄性小鼠中,每天对L. petauri LZys1进行口服测量.
- 用于肠道微生物群分析的16S rRNA测序.
- 肝肠胆酸概况和血清生物化学参数的量化.
主要成果:
- L. petauri LZys1增加了体重,肝脏质量和血清氨基转移酶.
- 肠道微生物群的多样性和丰富性下降.
- 胆汁酸概况被抑制,与低调的胆汁FXR/FGF15信号相关.
- 降低FGF15破坏了肝脏FGFR4/FXR,损害了胆酸代谢和脂肪酸氧化.
结论:
- L. petauri LZys1通过肠道微生物群调节影响肝功能.
- 阴茎的FXR-FGF15轴是这些效应的关键调解器.
- 益生菌的使用可能会破坏宿主胆酸代谢和肝功能.
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