与微生物组和代谢功能障碍相关的脂肪性肝病
Diren Beyoğlu1, Jeffrey R Idle1,2
1Department of Pharmaceutical and Administrative Sciences, College of Pharmacy and Health Sciences, Western New England University, Springfield, MA 01119, USA.
International journal of molecular sciences
|April 17, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 涉及肝脏脂肪的积累. 这篇评论探讨了肠道和肝脏的微生物群.
科学领域:
- 微生物学 微生物学
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 具有过度的肝脂肪积累,炎症和潜在的损伤的特征.
- 肠道和肝脏的微生物群在MASLD的发病过程中发挥着重要作用.
- 菌体 (菌体) 越来越多地被认为对微生物群落和疾病状态的影响.
研究的目的:
- 审查组织微生物群,包括肠道和肝脏微生物在MASLD中的作用.
- 探索细菌菌体在MASLD中的历史,发生和影响.
- 定义微生物群在MASLD中的胆汁酸和食氨基酸 (托,丁) 以及它们的代谢物代谢.
主要方法:
- 现有文献的叙述性审查.
- 评估肠道和肝脏微生物群的组成和功能.
- 对菌体作用和菌体治疗潜力的分析.
- 检查胆汁酸和特定的饮食成分的微生物代谢.
主要成果:
- 牙周炎和肠道失生症都可能导致MASLD的发展.
- 特定的微生物及其代谢物与MASLD的病原发生有关.
- 针对微生物群的疗法,包括菌体疗法,对MASLD治疗有希望.
结论:
- 微生物群,包括菌体,是MASLD发展和进展的核心.
- 针对微生物群的新型治疗策略为MASLD管理提供了新的途径.
- 菌体疗法虽然尚未获得FDA临床使用的批准,但仍在积极调查中,可能是MASLD的未来治疗方法.
关键词:
马斯尔德 马斯尔德是什么意思细菌菌体是一种细菌体.胆汁酸 胆汁酸 胆汁酸这种疾病叫做dysbiosis.这种内分泌物是endolysins.这就是histidine.霍林斯霍林斯是什么意思断断续续的禁食是一种禁食.我们的微生物群.菌体疗法是一种菌体疗法.益生菌是一种益生菌.托芬三聚氨酸是什么更多相关视频
相关概念视频
01:24Overview of Lipid Metabolism
828
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
828
01:30Liver Physiology
381
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
381
01:24Liver Regeneration
3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
01:24Chronic Pancreatitis I: Introduction
56
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
56
01:26Diseases of the Liver and Gallbladder
349
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
349