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笔素水解剂和奇托桑微囊的合成,表征和初步分析

Ruimin Li¹, Wenkui Song², Shijia Huang¹

¹Yantai Key Laboratory of Characteristic Agricultural Bioresource Conservation & Germplasm Innovative Utilization, School of Life Sciences, Yantai University, Yantai 264005, China.

International journal of molecular sciences

|April 17, 2025

概括

笔素水解剂 (SPTH) 用β-基托 (SPC) 进行微封装,以提高稳定性和生物可用性. 这种新的交付系统改进了SPTH.

科学领域:

生物技术是生物技术.
食品科学食品科学食品科学
材料科学材料科学材料科学

背景情况:

笔 (SP) 是一个丰富的蛋白质 (64.41%) 和素 (26.03%).
甲氨酸是鱼笔中最丰富的氨基酸.
提高SP水解盐的稳定性和生物可用性对于其应用至关重要.

研究的目的:

使用SPβ-基托 (SPC) 开发SP素化物 (SPTH) 的微囊.
为了优化SPTH/SPC微囊的制备条件,使用超声波乳化.
评估微囊的物理化学特性,体外释放和生物活性.

主要方法:

超声波乳化技术用于微封装.
优化SPC度 (2%),SPTH度 (4毫克/毫升),核心与壁的比率 (1:3),和超声波时间 (20分钟).
使用FTIR,XRD,DSC,SEM和体外消化研究进行表征.

主要成果:

在最佳条件下,产生了具有58.95%SPTH装载能力的微囊.
描述证实了成功封装,良好的热稳定性,小颗粒大小和高封装效率.
试验室消化显示有针对性的肠道释放 (69.32%) 和增强了消化的SPTH的抗氧化活性.

结论:

使用SPC进行微封装有效地提高了SPTH的稳定性和生物可用性.
开发的微囊为稳定性和生物可用性差的生物活性化合物提供了有前途的输送系统.
这种方法改善了鱼笔衍生的生物活性的利用.

关键词:

抗氧化剂活性抗氧化剂活性微囊中的微囊.鱼笔 trypsin 的水解物.结构性特征的结构性特征.这是一种β-基托桑.

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