在肝细胞癌中识别癌症干细胞相关的基因特征,基于单细胞RNA-Seq和批量RNA-Seq分析
Jing Wu1, Xu Liu1, Sheng Huang1
1Medical School, Hubei Minzu University, Enshi 445000, China.
International journal of molecular sciences
|April 17, 2025
概括
这项研究确定了九种癌症干细胞生物标志物 (BCSCs),以预测肝肝细胞癌 (LIHC) 患者的结果. 高风险LIHC患者的生存率较低,这表明个性化癌症治疗的新模式.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 免疫学 免疫学 免疫学
背景情况:
- 癌症干细胞 (CSC) 驱动肝肝细胞癌 (LIHC) 的进展,治疗耐药性和复发.
- 确定LIHC的预后生物标志物对于开发有效的治疗方法至关重要.
研究的目的:
- 在LIHC中探索癌症干细胞生物标志物 (BCSCs) 的预后意义.
- 开发基于BCSCs的LIHC预后风险模型.
主要方法:
- 对TCGA,ICGA和GEO (GSE156625) 数据集的综合分析,包括批量和单细胞RNA测序.
- 开发和验证一个九个BCSC预后风险模型.
- 在瘤微环境 (TME) 中对免疫细胞组成和基因表达的表征.
主要成果:
- 一个基于九个BCSC的预后风险模型 (ADM,CCL5,CD274,DLGAP5,HOXD9,IGF1,S100A9,SOCS2,TNFRSF11B) 被开发出来.
- 高风险LIHC患者的整体存活期显著缩短.
- 在高风险和低风险组之间观察到不同的免疫细胞组成和基因表达模式,这表明免疫逃避独立于PD-L1.
结论:
- 开发的基于BCSC的风险模型有效预测LIHC患者的预后.
- 肝癌的进展可能涉及免疫逃避机制,不仅仅取决于PD-L1.
- 低风险的BCSC群体对各种疗法表现出潜在的敏感性,为个性化的LIHC治疗策略铺平了道路.
更多相关视频
11:28Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
8.5K
09:34A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
Published on: October 25, 2018
6.6K
相关概念视频
Cancer Stem Cells and Tumor Maintenance
4.6K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.6K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
3.4K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
3.4K
