在GDM怀孕中增加孕前风险:SIRT1 rs12778366多态和端粒长度SIRT1的作用
Olga Dmitrenko1, Nataliia Karpova1, Malik Nurbekov1
1Federal State Budgetary Institution "Research Institute of Pathology and Pathophysiology", 125315 Moscow, Russia.
International journal of molecular sciences
|April 17, 2025
概括
孕期糖尿病和子宫前的妇女的端粒较短. 一种特定的SIRT1基因变异 (rs12778366) 与这些怀孕中的端粒缩短和先兆子风险增加有关.
科学领域:
- 产科和妇科 产科和妇科
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 孕前 (PE) 和孕期糖尿病 (GDM) 是重要的妊娠并发症.
- 这些条件共享了潜在的病理生理路径.
- 端粒长度和遗传因素与妊娠障碍有关.
研究的目的:
- 调查SIRT1基因多态 (rs12778366和rs7895833) 与孕妇患有GDM,有PE和没有PE的相对端粒长度 (RTL) 之间的关联.
- 确定SIRT1变异和RTL是否可以作为GDM怀孕中PE风险的生物标志物.
主要方法:
- 来自被诊断患有GDM的孕妇的DNA分析,包括那些同时存在PE的孕妇.
- 使用定量实时PCR测量RTL并对SIRT1多态进行基因定型.
- 进行了统计分析,以评估基因型,RTL和PE风险之间的关联.
主要成果:
- 与对照组相比,患有GDM和PE的女性的相对端粒长度明显较短.
- SIRT1 rs12778366多态的TC基因型与患PE的风险增加了4.48倍 (OR = 4.48;95% CI 1.54-13.08;p = 0.003).
- 在PE组中观察到异构体TCrs12778366基因型的更高患病率,以及短端粒.
结论:
- 这种SIRT1基因变异rs12778366显着与GDM女性的端粒缩短和孕前的风险增加有关.
- 这种特定的SIRT1变异可能作为一个潜在的预测生物标志物来评估GDM怀孕中产前风险.
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