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固体瘤中B7H3表达的预后意义:系统性审查和元分析

Sylwia Mielcarska¹, Agnieszka Kula², Miriam Dawidowicz²

¹Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 19 Jordana St., 41-800 Zabrze, Poland.

International journal of molecular sciences

|April 17, 2025

概括

过度表达B7H3 (CD276) 是固体瘤的负预后指标,影响整体存活率,无病存活率和无进展存活率. 这一元分析证实B7H3是预测各种癌症患者结果的潜在生物标志物.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
生物标志物发现发现

背景情况:

B7H3 (CD276) 是一种免疫调节分子,通过抑制性T细胞信号传递参与免疫逃避.
固体瘤中的高B7H3表达和正常组织中的低水平使其成为有希望的癌症免疫治疗标.
之前对B7H3对生存结果的影响的研究已经产生了不一致的结果,需要进一步调查.

研究的目的:

进行元分析,评估B7H3表达与固体恶性瘤的预后参数之间的关系.
为了澄清B7H3在癌症患者的预后意义.

主要方法:

在PubMed,科学网络 (WOS),Cochrane,SCOPUS和Embase数据库中进行了全面的文献搜索,截至2024年11月.
使用R研究室 (版本4.3.2) 进行了统计分析.
分析包括51项研究,共11135名患者.

主要成果:

B7H3过度表达被确定为总生存 (OS),无疾病生存 (DFS),无进展生存 (PFS),无复发生存 (RFS) 和癌症特异性生存 (DSS) 的显著负预测因素.
危险比率 (HR) 表示所有生存终点的风险增加,例如,HR=1.71 OS (p < 0.0001) 和HR=2.02 DFS (p < 0.0001).
敏感性分析证实了研究结果的稳定性,尽管观察到异质性.

结论:

过度表达B7H3始终与固体瘤患者的生存结果较差有关.
B7H3显示出作为固体恶性瘤的有价值的预后生物标志物的潜力.
进一步的研究可以探索在癌症治疗中针对B7H3的治疗策略.

关键词:

B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 没有疾病的生存率 (DFS)疾病特异性生存率 (DSS)这是一个元分析.总体生存时间 (OS)没有进展的生存率 (PFS)没有复发的生存率 (RFS)固体瘤是一种固体瘤.

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