慢性炎症疾病和心血管风险:目前的见解和最佳管理的未来战略
Stefano Cacciatore1,2, Silvia Andaloro3, Marco Bernardi4
1Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.
慢性炎症显著增加心血管疾病 (CVD) 的风险,特别是在患有炎症疾病的患者中. 目前的风险评分不足,需要新的策略来更好地评估和管理心血管风险.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 炎症研究 炎症研究
背景情况:
- 慢性炎症是动脉样硬化和心血管疾病 (CVD) 进展的关键因素.
- 患有慢性炎症性疾病 (例如,IBD,风湿学,自身免疫性疾病) 的患者面临更高的重大心脏不良事件 (MACE) 风险.
- 目前的心血管风险 (CVR) 评估工具往往低估了这些人群中的风险.
研究的目的:
- 检查慢性炎症,免疫调节,动脉样硬化,血栓形成和心血管事件之间的联系.
- 审查关于抗炎和免疫调节治疗心血管疾病的流行病学和临床试验数据.
- 确定知识差距,并提出未来的研究方向,以改善慢性炎症疾病中的CVR管理.
主要方法:
- 对生理病理学机制的叙述性审查.
- 流行病学研究和临床试验的分析.
- 探索抗炎和免疫调节治疗对心血管结果的影响.
主要成果:
- 慢性炎症,免疫调节和动脉样硬化是导致心血管事件的相互联系的途径.
- 有证据表明,抗炎和免疫调节疗法对心血管有潜在的益处.
- 现有的CVR得分不足以准确评估慢性炎症病患者的风险.
结论:
- 在患有慢性炎症疾病的患者中,急需改善心血管风险分层.
- 未来的研究应该专注于新的生物标志物 (脂管学,蛋白质学,炎症标志物,微生物群) 和先进的成像.
- 量身定制的干预措施对于优化这种高危人群的心血管结果至关重要.
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