在化物暴露下从牙植入物释放的颗粒与巨细胞相互作用
Waad Kheder1, Soumya Sheela2, A R Samsudin1
1College of Dental Medicine, University of Sharjah,PO Box: 27272, Sharjah, UAE.
Brazilian dental journal
|April 17, 2025
概括
化物和pH水平显著影响牙科植入物中颗粒的释放. 高酸度和化物释放微粒子,而较低的水平释放纳米粒子,影响巨细胞的反应,并可能导致植入物失败.
科学领域:
- 生物材料科学 生物材料科学
- 牙科植入物学 牙科植入物学
- 免疫学 免疫学 免疫学
背景情况:
- Ti6Al4V 牙植入物被广泛使用.
- 表面特性影响植入物性能.
- 颗粒物释放和随后的生物反应是关键问题.
研究的目的:
- 为了研究化物和pH对Ti6Al4V牙植入物释放的颗粒的影响.
- 为了将颗粒大小与巨细胞吸收和炎症性细胞因子表达相关联.
- 了解植入周围炎症的机制.
主要方法:
- 将Ti6Al4V植入物浸入各种化物度和pH值的溶液中.
- 扫描电子显微镜用于表面分析.
- 对颗粒大小和度的浸泡溶液的分析.
- 评估巨细胞对IL-1β和IL-8的摄取和表达.
主要成果:
- 高化物和酸度导致微粒的释放 (高达4551.7nm).
- 低化物,中性和性条件导致纳米粒子释放 (431.2484.5nm).
- 巨细胞显示了增加的纳米粒子吸收,而不会损害膜,并增加了IL-1β和IL-8的表达.
结论:
- 化物和pH值是影响牙植入物释放颗粒的关键因素.
- 释放的纳米颗粒很容易被巨细胞吸收,引发炎症反应.
- 这些炎症反应可能会破坏骨质细胞-骨质细胞平衡,导致植入物骨质整合失败.
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