氧化应激,肠道微生物群和细胞外囊:相互连接的途径和治疗潜力
Bo Ma1, Muttiah Barathan1, Min Hwei Ng1
1Department of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
International journal of molecular sciences
|April 17, 2025
概括
氧化应激 (OS) 和肠道微生物群失衡显著影响慢性疾病. 了解它们的复杂相互作用,包括细胞外囊泡 (EVs) 信号传输,是开发有针对性的疗法以改善健康的关键.
科学领域:
- 微生物学 微生物学
- 生物化学 生化学
- 免疫学 免疫学 免疫学
背景情况:
- 氧化应激 (OS),反应性氧物种 (ROS) 和抗氧化剂的不平衡,破坏细胞平衡,并导致慢性疾病.
- 肠道微生物群失调与慢性炎症,代谢功能障碍和各种病理有关.
- 肠道微生物群在免疫调节,新陈代谢和整体健康方面发挥着至关重要的作用.
研究的目的:
- 综合分析氧化应激和肠道微生物群之间的复杂关系.
- 探索细胞外囊泡 (EVs) 在OS和肠道微生物之间调解交叉语音中的作用.
- 对OS相关疾病的现有和潜在的治疗策略进行审查.
主要方法:
- 文献综述和现有关于氧化应激,肠道微生物群和细胞外囊泡的研究的综合.
- 分析这些因素之间的相互作用背后的分子机制.
- 评估新兴的治疗干预措施.
主要成果:
- 肠道系统和肠道失生症相互关联,加剧慢性疾病的发展.
- 细胞外囊泡 (EVs) 作为肠道微生物群和宿主之间的细胞通信的关键媒介,影响免疫和代谢反应.
- 有证据表明,OS和肠道微生物群的组成和功能之间存在复杂的双向影响.
结论:
- 向治疗,包括益生菌,抗氧化剂和便微生物群移植,显示出对管理OS相关疾病的承诺.
- 通过EVs了解分子信号提供了新的治疗途径.
- 对OS-微生物群相互作用的机制进行进一步的研究对于推进个性化医学至关重要.
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