推进法医人类时间年龄估计:过去15年的生化,遗传和表观遗传方法:系统性审查
Beatrice Marcante1,2, Laura Marino1, Narjis Elisa Cattaneo1
1Legal Medicine Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35122 Padova, Italy.
International journal of molecular sciences
|April 17, 2025
概括
法医年龄估计使用生化,遗传和表观遗传标记. DNA甲基化显示出高精度,但在刑事调查中可靠的识别需要标准化.
科学领域:
- 法医科学 法医科学 法医科学
- 生物化学 生化学
- 遗传学 是一个遗传学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 法医年龄估计对于识别未知的个人和缩小嫌疑人池至关重要.
- 在过去的15年里,使用生化,遗传和表观遗传标记在年龄预测方面取得了重大进展.
研究的目的:
- 审查和总结法医年龄估计技术的进展.
- 确定最有前途的生物标志物和该领域的剩余挑战.
主要方法:
- 在PubMed上进行了系统的文献搜索,选择了155项遵循PRISMA指南的研究.
- 符合条件的研究重点是放射性碳测年法,酸种族化,线粒体DNA分析,T细胞受体切除圆,RNA分析,端粒和DNA甲基化.
- 在表中总结了过去15年的数据.
主要成果:
- 基因甲基化已成为跨不同人群和年龄组预测年龄的高度准确方法.
- 仍然存在挑战,包括预测准确度的变化,样本退化和缺乏标准化.
- 综合多种生物标志物的多模式方法显示出提高可靠性的潜力.
结论:
- 进一步标准化,验证和技术整合对于提高法医年龄估计至关重要.
- 这些努力是必要的,以满足法医科学的需求,并解决伦理方面的考虑.
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