帕拉/诺伯伦合作催化三重功能化:碳amylation/双取消 (异质) 酸
Yi-Xin Chai1, Yu-Fan Yang1, Feng-Yu Zhang1
1Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, School of Pharmacy, Yantai University, Shandong, Yantai, 264005, P. R. China. chemzyp@foxmail.com.
一种新的催化反应使得从简单的酸合成复杂的含异环. 这种方法使用N-受保护的基甲基化进行乙化,实现直接的C-H功能化,无需催化剂中毒.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 异环化学 异环化学
背景情况:
- 含的多循环异循环是药品和材料中重要的结构动图.
- 构建这些复杂分子的高效合成方法非常受欢迎.
- 与传统的交叉合反应相比,直接的C-H功能化提供了一种更为原子经济的方法.
研究的目的:
- 开发一种新型的催化系统,用于合成含有的多循环异循环.
- 通过分子间脱水环循环利用 heteroaryl iodides 作为起始材料.
- 在直接的C-H功能化策略中使用N-受保护的基甲基甲基化物作为乙基化剂.
主要方法:
- (Pd) 和N-乙胺 (NBE) 催化了分子间脱水循环反应.
- 直接的C-H功能化各种 heteroaryl 化物.
- 使用N-受保护的甲基甲基甲基化物进行化.
主要成果:
- 通过一种新的Pd/NBE催化系统,成功合成了含的多环异环.
- 证明了 heteroaryl iodides 的分子间脱水循环.
- 通过使用N-受保护的基甲基甲基化物作为乙源来实现化.
- 通过直接C-H功能化而获得的产品,而无需催化剂被异质原子中毒.
结论:
- 已经建立了一种新且高效的Pd/NBE催化方法,用于合成含的多循环异循环.
- 开发的协议允许直接的C-H功能化化,提供了一个精简的合成路线.
- 该方法强大,避免了诸如催化剂中毒等常见问题,使其对合成化学家有价值.
更多相关视频
19:58Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
08:12A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
相关概念视频
Halogenation of Alkenes
Consider the bromination of cyclopentene. Molecular bromine is polarized in the proximity of the π electrons of cyclopentene. An electrophilic bromine atom adds across the double bond, forming a cyclic bromonium ion intermediate.
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo, or cyano...
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)