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预后营养指数与儿童血管的相关性和预测值
Fangting Liu1, Nan Quan1, Ping Liu1
1Department of Pediatric Cardiovasology, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
预后营养指数 (PNI) 在患有血管 (VVS) 的儿童中较低,可以帮助预测VVS. 较低的PNI水平与儿科患者的VVS风险增加有关.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 临床营养学 临床营养学
- 免疫学 免疫学 免疫学
背景情况:
- 血管 (VVS) 是儿童的常见原因之一.
- 预后营养指数 (PNI) 反映了营养状况和免疫功能.
- PNI和儿科VVS之间的关系尚未得到充分证实.
研究的目的:
- 调查儿童中PNI和VVS之间的相关性.
- 评估PNI的预测价值,用于诊断儿科VVS.
- 确定PNI是否是VVS的独立保护因素.
主要方法:
- 一项涉及151名被诊断患有VVS的儿童和152名健康对照者的病例控制研究.
- 测量血清白蛋白,血清环球蛋白,白蛋白/环球蛋白比率 (AGR) 和周围血液淋巴细胞绝对计数 (Lc).
- 使用接收器运行特征 (ROC) 曲线计算PNI并分析其预测值.
主要成果:
- 与对照组相比,患有VVS的儿童的PNI,血清白蛋白,AGR和淋巴细胞计数显著降低 (P <0.05).
- 对于VVS诊断,PNI显示了中等的预测值 (曲线下的面积=0.814).
- 一个PNI切线为55.00给出了90.73%的灵敏度和54.61%的特异性VVS预测. PNI是VVS的一个独立的保护因子 (OR = 0.65,P < 0.001).
结论:
- 在儿童中,PNI与VVS相关.
- PNI对于诊断儿科VVS具有预测价值.
- PNI作为一个独立的保护因素,防止VVS在儿童中发生.
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