口服生物增强黄素在干眼疾病中的作用
Dikshit Kapil1, Aafreen Bari1, Namrata Sharma1
1Cornea, Cataract and Refractive Surgery, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, Delhi, India.
Indian journal of ophthalmology
|April 17, 2025
概括
在临床试验中,口服生物增强的黄素显著改善了干眼疾病 (DED) 症状和膜稳定性. 这种天然化合物为轻度至中度DED患者提供了安全有效的治疗选择.
科学领域:
- 眼科医生 眼科 眼科
- 营养保健品 营养保健品
- 临床研究 临床研究
背景情况:
- 干眼病 (DED) 影响着相当一部分人口,导致不适和视力受损.
- 目前对DED的治疗方法效果各不相同,并且可能会产生副作用.
- 需要安全有效的治疗方案来管理DED.
研究的目的:
- 评估口服生物增强黄素作为干眼疾病 (DED) 治疗的疗效和安全性.
- 评估口服生物增强黄素对DED患者眼表面健康的关键客观参数的影响.
主要方法:
- 一项随机,双面膜,安慰剂控制的临床研究,涉及40名双边轻度至中度DED患者.
- 患者接受了局部碳素甲基纤维素与口服安慰剂或局部碳素甲基纤维素与口服生物增强的黄素三个月.
- 目标DED参数,包括OSDI得分,撕裂半径高度 (TMH),撕裂体积,撕裂破裂时间 (TBUT),非侵入性破裂时间 (NIBUT),脂质层厚度 (LLT) 和眼睛红色,在基线和随访时被测量.
主要成果:
- 与安慰剂相比,口服生物增强的黄素组在OSDI得分,TMH,水量,TBUT,NIBUT,LLT和柱红色方面显著改善 (所有人P <0.05).
- 在黄素组中,没有观察到肢体发红,角膜染色或希尔默测试结果的显著改善.
- 在两组中,少数患者报告了轻微的不良药物反应.
结论:
- 口服生物增强黄素是一种对轻度至中度干眼疾病 (DED) 的安全有效治疗方法.
- 它在改善眼膜稳定性,脂质层厚度,眼半径高度和减少眼睛红色方面显示出显著的益处.
- 黄是一种有前途的治疗剂,用于管理DED,补充现有治疗方法.
相关概念视频
01:11Direct-Acting Cholinergic Agonists: Therapeutic Uses
1.9K
Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...
1.9K
01:30Indirect-Acting Cholinergic Agonists: Pharmacological Actions
1.8K
Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
1.8K
01:20Sulfur Assimilation
554
Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
554