大脑休息状态功能连接调解了与年龄相关的身体活动参与度下降
Meishan Ai1,2, Emma M Tinney1,2, Goretti España-Irla3,2
1Department of Psychology, Northeastern University.
概括
身体活动的参与度随着年龄的增长而下降,从49岁开始. 对行为调节至关重要的突出网络中的功能连接性减少是这种下降的基础,为干预提供了目标.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 认知科学 认知科学
背景情况:
- 在老年人中,体育活动的参与通常会下降.
- 了解影响体育活动的因素对于促进老龄化人口体育活动至关重要.
- 执行功能是一个关键的神经认知资源,可能支持体育活动参与.
研究的目的:
- 为执行功能网络在体育活动参与中的作用提供神经生物学证据.
- 为了检查大脑网络功能连接和身体活动水平在成年人一生中的关联.
- 调查与年龄相关的身体活动下降背后的神经机制.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 数据来自剑桥衰老与神经科学中心 (Cam-CAN) 队列 (N=18-81岁).
- 收集了自我报告的体育活动参与度.
- 分析了前端对面网络和突出网络中的功能连接.
主要成果:
- 从49岁开始,体育活动的参与率显著下降.
- 在前侧状网络 (后侧状,状区域,前状) 和突出网络 (状-状-状,状,前端-岛屿区域) 中的功能连接与身体活动有关.
- 突出网络中的功能连接介导了与年龄相关的身体活动下降,但不是前对对面网络.
结论:
- 身体活动参与度在中年降低,与执行功能相关的神经机制.
- 突出网络功能连接,支持抑制控制和行为调节,是与年龄相关的身体活动下降的潜在神经基质.
- 这些发现支持了执行功能支持体育活动的假设,并确定了促进老年人体育活动的干预措施的潜在神经点.
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