在中年妇女中,COVID-19流行病相关暴露和认知功能
Siwen Wang1,2, Anthony Menor2, Lori B Chibnik3,4,5,6,7
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
JAMA network open
|April 17, 2025
概括
在COVID-19疫情爆发后的2.5年内,中年女性的认知功能没有受到显著影响. 在SARS-CoV-2感染或COVID-19后的疾病中,与认知能力下降没有统计学上显著的关联.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 随着COVID-19的流行,潜在的认知能力下降风险存在,包括丧亲和SARS-CoV-2感染.
- 了解大流行对认知功能的影响对于公共卫生战略至关重要.
研究的目的:
- 调查COVID-19流行病,与流行病相关的暴露和中年妇女的认知功能之间的联系.
- 评估疫情前和期间妇女的认知变化.
主要方法:
- 一项使用护士健康研究II.数据的队列研究.
- 分析了51-76岁的5191名女性的认知评估,比较了大流行前 (2014-2020) 和大流行期间 (2020-2022) 的时间.
- 根据年龄,教育,实践效应和并发症进行统计调整;针对SARS-CoV-2感染和COVID-19后情况进行亚组分析.
主要成果:
- 在疫情前和疫情期间的评估之间,没有观察到认知功能 (精神运动速度,注意力,学习,工作记忆,总分) 的显著差异.
- 虽然SARS-CoV-2感染或COVID-19后的情况与参与者的子集的认知功能下降有关,但这些发现缺乏统计学意义,并且具有广泛的置信区间.
- 这项研究发现,COVID-19大流行与这一群体的认知能力下降在患病后长达2.5年的时间之间没有联系.
结论:
- COVID-19 流行病和相关事件与中年女性的认知能力下降没有联系,在它开始后的 2.5 年内.
- 需要进一步的研究来确定SARS-CoV-2感染和COVID-19后条件对认知功能的长期影响.
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