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阻塞性睡眠呼吸暂停的成年人中阴骨位置的性别差异:系统性审查和元分析
Diana Graizel-Armoni1, Tzvika Greenbaum2, Tamar Brosh3
1Department of Oral Rehabilitation, Faculty of Medical and Health Sciences, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel.
Dental and medical problems
|April 17, 2025
概括
舌骨位置的性别差异影响阻塞性睡眠呼吸暂停 (OSA) 的严重程度. 这次元分析发现,在患有OSA的男性和女性之间,状骨-下平面距离 (HMP) 中存在显著差异.
科学领域:
- 医学研究 医学研究
- 睡眠的药物 睡眠的药物
- 人体解剖学 解剖学 解剖学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 的严重程度与舌骨的位置有关.
- 在舌骨解剖学中存在潜在的基于性别的变异.
- 在OSA患者中,雄骨位置的性别特定比较是有限的.
研究的目的:
- 在OSA患者中对状骨位置的性别特异进行元分析.
- 在男性和女性中研究状骨-下平面距离 (HMP) 和OSA严重程度 (AHI) 之间的关系.
主要方法:
- 在 Embase,MEDLINE 和 Web of Science 搜索了观测研究.
- 包括使用头脑成像学 (CEPH),多睡眠学 (PSG) 和对两性OSA患者的AHI数据的研究.
- 不包括评论,元分析和案例报告;使用SIGN检查清单评估偏见风险.
主要成果:
- 包括7项涉及718名患者的研究 (515名男性,203名女性).
- 在男性 (21.6毫米) 和女性 (17.8毫米) 之间发现了HMP平均值的显著差异 (p < 0.00001).
- HMP和AHI之间的相关性在女性 (r=0.423) 中是男性 (r=0.167) 的2.5倍.
结论:
- 性别显著影响OSA患者的状骨解剖变异.
- 识别特定于性别的OSA内型对于准确的诊断和治疗至关重要.
- 结果表明,需要针对OSA制定性别特定的治疗策略.
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