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维生素B在骨关节炎中的意想不到的作用:呼吁谨慎
Jingkai Di1, Liying Song2, Lujia Liu3
1Department of Orthopedics, Second Hospital of Shanxi Medical University, No. 382, Wuyi Road, Xinghualing District, Taiyuan, Shanxi, China. chuanxiang@sxmu.edu.cn.
Food & function
|April 17, 2025
概括
高摄入某些B族维生素可能会增加骨关节炎的风险,特别是在老年妇女中. 然而,叶酸可能会提供关节保护. 在补充之前,请咨询医生.
科学领域:
- 营养科学 营养科学
- 流行病学 流行病学
- 生物化学 生物化学
背景情况:
- 骨关节炎 (OA) 是一种普遍存在的退行性关节疾病.
- 维生素B在新陈代谢过程中起着至关重要的作用.
- 维生素B单独和组合对OA风险的具体影响需要进一步研究.
研究的目的:
- 研究B族维生素对骨关节炎的单独和联合作用.
- 为了确定与增加或减少OA风险相关的特定B族维生素.
- 探索B族维生素-OA关系中的潜在改变因素.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) 数据库 (2003-2018) 的数据.
- 针对单个B维生素协会的使用加权多重逻辑回归.
- 应用贝叶斯内核机器回归 (BKMR),加权量子素和 (WQS) 回归,以及量子素g计算 (qgcomp) 结合效应.
- 纳入限制立方线 (RCS) 对非线性关联的分析.
主要成果:
- 维生素B1,B2,B12和叶酸总量与OA的风险增加有关.
- 这些关联在65岁以上的个人和女性中更为明显.
- 混合效应模型表明,B族维生素的组合放大了OA风险,其中B2和B12是主要的贡献者.
- 叶酸在混合模型中显示出对骨和关节的保护作用.
结论:
- 摄入维生素B似乎加快了骨关节炎的发病和进展.
- 患有OA或高风险的个体应在补充维生素B方面保持谨慎.
- 需要进一步的研究来阐明B族维生素与关节健康之间的复杂相互作用.
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