Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Microtubule Associated Motor Proteins01:32

Microtubule Associated Motor Proteins

7.5K
Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular...
7.5K
Eukaryotic Compartmentalization01:37

Eukaryotic Compartmentalization

10.3K
One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal...
10.3K
Mitochondrial Protein Sorting01:39

Mitochondrial Protein Sorting

4.1K
Mitochondria are double-membrane organelles of the eukaryotes involved in cellular metabolism, signaling, ATP synthesis, and programmed cell death.  Each of these processes requires specific proteins and enzymes that must be correctly sorted to the right mitochondrial subcompartment for the proper functioning of the organelle.
Most of these mitochondrial proteins are encoded by the nucleus and imported to the mitochondria as unfolded or loosely folded precursors. Mitochondrial precursors...
4.1K
Protein Translocation Machinery on the ER Membrane01:28

Protein Translocation Machinery on the ER Membrane

4.2K
The translocon complex situated on the ER membrane is the main gateway for the protein secretory pathway. It facilitates the transport of nascent peptides into the ER lumen and their insertion into the ER membrane.
Sec61 protein conducting channel
In eukaryotes, the translocon complex comprises a core heterotrimeric translocator channel called the Sec61 complex. This channel includes three transmembrane proteins, Sec61α, Sec61β, and Sec61γ, and is the largest subunit of the...
4.2K
The Proteasome02:18

The Proteasome

8.3K
Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
8.3K
Cytoskeletal Accessory Proteins01:13

Cytoskeletal Accessory Proteins

2.9K
The cytoskeleton is an essential cell component that plays several structural and functional roles. However, the filaments that make up the cytoskeleton cannot function independently and depend on the accessory or ancillary proteins to effectively carry out their function. Accessory proteins associate with cytoskeletal filaments and their monomers, aiding filament formation and function. They also help in the cross-communication among cytoskeletal filaments. Cytoskeletal accessory proteins are...
2.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Author Correction: Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics.

Nature communications·2026
Same author

Expanding the human proteome with microproteins and peptideins.

Nature·2026
Same author

Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics.

Nature communications·2026
Same author

Translon: a single term for translated regions.

Nature methods·2025
Same author

LZTR1 is a melanoma oncogene that promotes invasion and suppresses apoptosis.

Oncogene·2025
Same author

The ERVK3-1 Microprotein Interacts with the HUSH Complex.

Biochemistry·2025
Same journal

Lactate as a Chemical Modification on Proteins and Metabolites.

Annual review of biochemistry·2026
Same journal

Nucleocytoplasmic Transport.

Annual review of biochemistry·2026
Same journal

Packaging of Single-Stranded RNA in Viruses and Virus-Like Particles.

Annual review of biochemistry·2026
Same journal

Shaping of the Infant Gut Microbiome by Milk Oligosaccharides.

Annual review of biochemistry·2026
Same journal

Proteostasis Deregulation by Metabolism Drives the Hallmarks of Cancer.

Annual review of biochemistry·2026
Same journal

JoAnne Stubbe's Radical Path: A Story of Passion, Curiosity, and Persistence.

Annual review of biochemistry·2026
查看所有相关文章

相关实验视频

Updated: May 11, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.3K

单核细胞微蛋白是什么?

Nadiya Jaunbocus1,2, Valerie Ebenki1,2, Haomiao Su1,2

  • 11Department of Chemistry, Yale University, New Haven, Connecticut, USA;

Annual review of biochemistry
|April 17, 2025
PubMed
概括
此摘要是机器生成的。

微蛋白,小蛋白质错过了基因组注释,在人体细胞中是众多和至关重要的. 它们在健康和疾病中的发现和功能正在迅速发展.

更多相关视频

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
08:07

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

Published on: August 2, 2015

8.0K
Eukaryotic Polyribosome Profile Analysis
09:16

Eukaryotic Polyribosome Profile Analysis

Published on: June 15, 2010

52.5K

相关实验视频

Last Updated: May 11, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.3K
Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
08:07

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

Published on: August 2, 2015

8.0K
Eukaryotic Polyribosome Profile Analysis
09:16

Eukaryotic Polyribosome Profile Analysis

Published on: June 15, 2010

52.5K

科学领域:

  • 生物化学和分子生物学
  • 基因组学就是基因组学.
  • 细胞生物学 细胞生物学

背景情况:

  • 微蛋白质是小的多 (<150个氨基酸),由于它们的尺寸和特性,传统的基因组注释通常会错过它们.
  • 数以千计的微蛋白从人类基因组中转化,在细胞和生理功能中发挥重要作用.
  • 微蛋白的失调或突变与神经退行和癌症等疾病有关.

研究的目的:

  • 审查关于真核微蛋白发现的当前知识.
  • 总结小开放式阅读框架 (sORF) 的特点及其表达方式.
  • 讨论微蛋白在不同的物种中已知的功能,从酵母到人类.

主要方法:

  • 审查现有文献和微蛋白研究领域的最新进展.
  • 专注于通过核糖体分析技术实现的发现.
  • 关于序列,表达式和功能数据的信息综合.

主要成果:

  • 在过去的15年中,全球微蛋白的发现显著加速.
  • 微蛋白涉及至关重要的细胞通路和生理过程.
  • 有证据表明,微蛋白质失调与各种人类疾病有关.

结论:

  • 微蛋白代表了一类重要的蛋白质,其功能非常重要.
  • 对微蛋白的持续研究对于理解基本生物学和疾病机制至关重要.
  • 微蛋白研究领域是充满活力和快速扩张的.