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暴露于碳酸会破坏神经发育,因为它会扰乱初级毛和ER恒温

Zhen Guan¹, Yingchao Liang¹, Zhiqiang Zhu¹

¹Laboratory of Translational Medicine, Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China.

Ecotoxicology and environmental safety

|April 17, 2025

概括

在怀孕期间暴露于碳酸可以通过破坏胚胎发育和ER平衡来引起神经管缺陷 (NTDs). 孕产妇服用伊诺西托补充剂可以预防这些严重的出生缺陷.

科学领域:

发展生物学发展生物学
毒理学毒理学毒理学
神经科学是一个神经科学.

背景情况:

碳酸 (Li2CO3) 被广泛用于双相情感障碍,并且越来越多地在环境中发现.
穿过胎盘,对胎儿发育构成风险,包括神经管缺陷 (NTD).
连接Li2CO3暴露与NTDs的机制在很大程度上是未知的.

研究的目的:

研究Li2CO3暴露在发育中的胚胎中引起NTD的机制.
评估Li2CO3对初级乳毛和内细胞网膜 (ER) 均质的影响.
评估伊诺西补充剂对Li2CO3诱导的发育毒性的保护作用.

主要方法:

怀孕的小鼠接受了Li2CO3注射,以模仿高暴露.
对胚胎进行了形态缺陷,初级乳毛长度和ER平衡的分析.
技术包括组织学,电子显微镜,PCR阵列,免疫光和生物信息学.

主要成果:

在胚胎神经管中,Li2CO3暴露诱导了外大脑和减少了初级毛的长度.
二氧化碳3破坏了ER平衡,并提高了HSP90AB1的调节,这是一个关键的ER调节器.
伊诺西托尔补充剂在试验室中部分恢复了眼的长度.

结论:

暴露于Li2CO3会破坏胚胎神经管的发育,因为它会损害初级毛和ER恒温.
HSP90AB1上调与Li2CO3诱导的NTD有关.
保持孕产妇内醇水平可以预防Li2CO3诱导的NTD,突出显示孕产妇和胎儿健康的风险.

关键词:

是的组成部分.神经发育神经发育怀孕怀孕怀孕怀孕细胞内膜网的恒常状态 (homeostasis)伊诺西托尔 (英诺西托尔) 是一种内醇.主要的乳毛是主要的乳毛.

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