世界各国的风湿性关节炎相关的间歇性肺病
Sascha L Heckert1, Tjardo D Maarseveen1, Emiel R Marges2
1Rheumatology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands.
Seminars in arthritis and rheumatism
|April 17, 2025
概括
风湿性关节炎 - 间歇性肺部疾病 (RA-ILD) 的发病率在全球范围内较低,尽管RA-ILD患者的疾病活性较高. 这项研究强调了不同国家的RA-ILD患病率及其与RA疾病活动的联系.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,可以影响多个器官,包括肺部.
- 风湿性关节炎 - 间歇性肺病 (RA-ILD) 是 RA 的严重并发症,影响患者的发病率和死亡率.
- 了解RA-ILD的全球发病率和风险因素对于患者管理至关重要.
研究的目的:
- 为了确定五个国家的RA-ILD的全球发病率.
- 调查RA疾病活动与RA-ILD发展之间的关联.
主要方法:
- 从五个国家的两个观察数据库 (METEOR,EAC) 分析了来自16663名RA患者的数据.
- RA-ILD的诊断是基于临床评估,包括胸部X射线或CT扫描.
- 统计分析探讨了随时间推移的疾病活动得分 (DAS28) 与RA-ILD发病率之间的关系.
主要成果:
- 根据国家,RA-ILD的患病率有所不同,从荷兰的0.09%到墨西哥的1.42%不等.
- 在荷兰 (3.8),印度 (1.6) 和南非 (6.6) 报告了每1000个患者年发生率.
- 与对照组相比,RA-ILD患者在诊断后观察到较高的疾病活性 (β=0.56),在DMARD使用方面没有显著差异.
结论:
- 在日常 RA 护理中,RA-ILD 发病率在全球不同人口中通常很低.
- 被诊断为RA-ILD的患者表现出增加的疾病活性,并且更频繁地为ACPA阳性或有吸烟史.
- 这些发现强调了监测RA患者的肺部健康的重要性,特别是那些疾病活性较高的患者.
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