类风湿性关节炎的睡眠障碍:发病率,风险因素和与痴呆症的关联
Roslin Jose George1, Rakesh Kumar1, Sara J Achenbach2
1Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.
Seminars in arthritis and rheumatism
|April 17, 2025
概括
患有类风湿性关节炎 (RA) 的人患睡眠障碍 (SD) 的风险更高,尤其是失眠. 心血管疾病和精神健康状况,如抑郁和焦虑,与RA患者的SD风险增加有关.
科学领域:
- 类风湿病学 类风湿病学
- 睡眠医学 睡眠医学
- 神经学 神经学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,影响关节.
- 睡眠障碍 (SD) 是常见的,但在RA群体中研究不足.
- 需要进一步调查RA,SD和痴呆风险之间的关系.
研究的目的:
- 为了确定与非RA个体相比,RA患者中SD的发病率.
- 确定与RA中SD发展相关的风险因素.
- 评估RA队列中事件SD和痴呆症之间的联系.
主要方法:
- 在明尼苏达州对年龄≥50岁的个人进行了回顾性队列研究.
- 根据年龄,性别和RA发病率年份,与非RA比较者匹配1:1的RA患者.
- 从医疗记录中收集了关于SD,心血管疾病 (CVD) 风险因素和并发症的数据.
主要成果:
- 关节炎患者显著增加任何事件SD (HR 1.34) 和失眠 (HR 1.34) 的风险.
- 肥胖,失脂症,心血管疾病,抑郁症,焦虑症和最近的RA诊断年是RA中SD的危险因素.
- 在RA患者中,SD (总体或亚型) 和痴呆症之间没有发现显著的关联.
结论:
- 患有RA的人患上睡眠障碍,特别是失眠的风险更高.
- 心血管疾病,其风险因素,抑郁症和焦虑症有助于增加RA中SD风险.
- 该研究发现,在风湿性关节炎患者群体中,睡眠障碍和痴呆症之间没有显著的关联.
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