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mtDNA/RNA通过M1巨细胞极化促进的IFN-β-依赖性炎症反应增强了辐射诱导的abscopal效应

Yuting Gao¹, Boyi Yu², Linjing Li²

¹Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; School of Life Sciences, Northwest Normal University, Gansu Province, Lanzhou 730070, China.

International immunopharmacology

|April 17, 2025

概括

辐射诱导的abscopal效应 (RIAE) 涉及线粒体DNA和RNA激活免疫通路以产生IFN-β. 这促进了抗瘤反应,高LET碳离子显示出比X射线更大的有效性.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
辐射生物学辐射生物学

背景情况:

辐射诱导的腹膜效应 (RIAE) 抑制了远处的瘤,但其机制尚不清楚.
自会通过调节线粒体DNA (mtDNA) 和干扰素-β (IFN-β) 生产来影响RIAE.
在RIAE中IFN-β的下游途径需要进一步调查.

研究的目的:

阐明由mtDNA/RNA和IFN-β介导的RIAE的机制.
研究IFN-β在瘤微环境中的巨细胞两极分化中的作用.
为了比较高LET碳离子与低LETX射线在诱导RIAE方面的疗效.

主要方法:

在放射后的瘤细胞中分析mtDNA和mtRNA的积累.
对cGAS-STING和RIG-I-MAVS通路激活的评估.
通过STAT1激活评估IFN-β的产生和巨细胞极化 (M1表型).
通过高LET碳离子和低LETX射线诱导RIAE的比较.

主要成果:

放射治疗 (RT) 诱导了乳腺瘤细胞中的mtDNA和mtRNA积累.
mtDNA/mtRNA激活了cGAS-STING和RIG-I-MAVS通路,协同增加了IFN-β的产生.
在非辐射瘤中,IFN-β通过STAT1激活促进了M1巨分化.
高LET碳离子在诱导IFN-β和巨细胞极化方面比低LETX射线更有效.

结论:

mtDNA/RNA和IFN-β是RIAE的关键媒介.
在乳腺癌中,IFN-β是增强放射治疗免疫性的一种潜在目标.
高LET辐射可能更有效地引起RIAE.

关键词:

如果是IFN-β,那么它是什么?巨细胞是一个巨细胞.瑞亚电子公司 (RIAE)在 mtDNA/RNA 中.

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