在小鼠中,肠道微生物群通过肠心轴促进阻塞性睡眠呼吸暂停引起的高血压
Xiaotong Zhang1, Yanran Yin1, Yongjun Chen2
1Shanxi Provincial People's Hospital, The Fifth Clinical Medical College of Shanxi Medical University, 29 Shuang Ta East Street, Taiyuan 030001, China.
International immunopharmacology
|April 17, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 患者的肠道微生物群在小鼠中促进高血压. 这通过脂聚糖 (LPS) /类似收费受体4 (TLR4) /核因子-kappaB (NF-κB) 途径发生,这表明针对OSA相关高血压的微生物组向疗法.
科学领域:
- 微生物学 微生物学
- 心血管科学 心血管科学
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与高血压 (HTN) 有关,但涉及肠道微生物组的潜在机制尚未完全理解.
- 肠道功能障碍症与OSA相关的HTN病变发生有关.
研究的目的:
- 研究OSA患者肠道微生物群在诱导高血压中的因果作用.
- 为了阐明涉及OSA诱导的高血压中介于肠道微生物群的分子途径.
主要方法:
- 从健康对照组,OSA患者,高血压前OSA患者和高血压OSA患者的便微生物群移植到接受者小鼠中.
- 使用16S rDNA基因测序分析肠道微生物群的组成和功能.
- 评估大动脉组织中的脂聚糖 (LPS) /类似收费受体4 (TLR4) /核因子-kappaB (NF-κB) 信号通路.
主要成果:
- 与对照组相比,从OSA,OSA-pHTN和OSA-HTN组接受微生物群的小鼠表现出缩血压增加和大动脉损伤.
- 在这些群体中观察到失生症,肠道屏障功能受损 (减少阿克尔曼西亚,减少zonula occludens-1和Occludin),以及肠道衍生的LPS增加.
- 在与OSA相关的微生物群移植的小鼠中,发现了大动脉LPS,TLR4和酸化NF-κB表达的升高,特别是在内皮细胞中.
结论:
- 来自OSA患者的肠道微生物群具有促高血压效应.
- 由肠道衍生的LPS/TLR4/NF-κB通路是OSA诱导的高血压的关键调解者.
- 准肠道微生物组稳态可能为OSA相关的高血压提供治疗策略.
相关概念视频
Sleep Apnea
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...


