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Selina J Chang¹, Kabir S Grewal¹, Amrish Selvam²

¹From the University of Pittsburgh School of Medicine (S.J.C. and K.S.G.), Pittsburgh, Pennsylvania, USA.

American journal of ophthalmology

|April 17, 2025

概括

视网膜静脉封闭 (RVO) 的临床试验显示,人口统计报告有所改善,亚裔和黑人参与者代表性增加. 然而,西班牙裔/拉丁裔人数仍然不足,这强调需要更具包容性的RVO试验招生策略.

科学领域:

眼科医生眼科眼科
临床试验临床试验
健康公平卫生公平

背景情况:

视网膜静脉封闭 (RVO) 是由于视网膜血管疾病导致视力丧失的主要原因.
临床试验往往不足以代表少数群体,影响研究结果的概括性和公平性.
了解RVO试验中的人口趋势对于改善健康公平至关重要.

研究的目的:

在RVO临床试验中分析民族种族人口统计报告的变化.
评估RVO试验参与者的种族和民族组成的演变.
调查参与者人口统计和试验赞助商/合作者类型之间的相关性.

主要方法:

在美国进行的RVO临床试验的回顾性趋势分析.
数据来源于ClinicalTrials.gov,与2022年美国人口普查局人口统计数据进行比较.
评估参与者,赞助商和合作者的种族分布变化随着时间的推移.

主要成果:

在RVO试验中的民族种族报告显著增加,从20.7% (2012-2017) 增加到92.9% (2017-2022).
亚裔和黑人参与者的比例增加,而白人和西班牙裔/拉丁裔参与者的比例减少.
在RVO试验招生人口统计数据和美国普通人口之间存在显著差异;政府/学术赞助商与增加的黑人代表性相关.

结论:

在RVO试验中的种族和民族人口统计文档得到了实质性的改进.
虽然亚裔和黑人的代表性有所增长,但西班牙裔/拉丁裔人口仍然代表性不足.
加强在RVO临床试验招生中的包容性是必要的,以确保公平的代表性.

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