在柬埔寨住院的儿童中,Clostridioides (Clostridium) 困难在柬埔寨住院的儿童中
Lengsea Eng1, Kefyalew Addis Alene2, Deirdre A Collins3
1School of Population Health, Curtin University, Perth, Western Australia, Australia; Department of Laboratory, Calmette Hospital, Phnom Penh, Cambodia.
Anaerobe
|April 17, 2025
概括
柬埔寨儿童中患有困难菌感染 (CDI) 很普遍,抗微生物药物的使用是关键的危险因素. 新型和非毒性菌株很常见,这凸显了亚洲进一步分子流行病学研究的需要.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 儿科 儿科 儿科
背景情况:
- 儿童是Clostridioides difficile在医疗保健和社区环境中的潜在传播者.
- 在儿童群体中,全球对Clostridioides difficile感染 (CDI) 的兴趣越来越大.
- 了解儿童CDI流行病学对于公共卫生战略至关重要.
研究的目的:
- 确定柬埔寨住院儿童中Clostridioides difficile的流行情况.
- 在这个人群中识别与Clostridioides difficile感染相关的风险因素.
- 为了描述循环的Clostridioides difficile菌株的分子类型.
主要方法:
- 从柬埔寨金边住院的儿童 (2022年6月至2023年3月) 收集了便样本.
- 艰难的Clostridioides是从样本中培养的.
- 使用毒素基因PCR和PCR核型定型来分析分离物.
主要成果:
- 在122名住院儿童中,Clostridioides difficile在38.5%的儿童中被检测到.
- 在25.5%的阳性病例中发现了毒性菌株,其中RT 012占主导地位.
- 新型菌株占隔离物的70%;抗菌药物的使用 (OR=5.15) 和其他药物 (OR=13.02) 是显著的风险因素.
结论:
- 在住院的柬埔寨儿童中观察到Clostridioides difficile的高患病率.
- 该研究发现了很大一部分非毒性和新型菌株.
- 建议对亚洲的分子流行病学研究进行进一步的研究,包括全基因组测序.
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