通过高强度皮质内微刺激,在空间和时间上不匹配的血流和神经元活动
Alexandra Katherine Isis Yonza1, Lechan Tao1, Xiao Zhang1
1Department of Neuroscience, Faculty of Health and Medical Science, University of Copenhagen, DK-2200, Copenhagen N, Denmark.
Brain stimulation
|April 17, 2025
概括
高强度皮内微刺激 (ICMS) 破坏神经血管合 (NVC),损害血液流向激活的大脑区域. 较低的ICMS强度可以保持NVC,这对于有效的神经修复功能至关重要.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 生理学 生理学 生理学
背景情况:
- 皮内微刺激 (ICMS) 对神经假体脑机界面至关重要.
- 神经血管合 (NVC) 将神经元活动与大脑血流联系起来,但其对ICMS的反应尚不清楚.
- 在ICMS期间低于最佳的NVC可能会通过限制能量供应来阻碍神经假肢的性能.
研究的目的:
- 调查ICMS和NVC之间的准确关系.
- 为了确定ICMS强度如何影响神经元和血流反应.
- 了解对神经假肢设计的影响.
主要方法:
- 在转基因小鼠中利用广场成像 (WFI),激光光斑成像 (LSI) 和两光子显微镜 (TPM).
- 测量了神经元和血管壁细胞 (VMC) 中的 (Ca2+) 动态.
- 评估了来自电极的不同距离的血管内直径和皮质组织反应.
主要成果:
- 高ICMS强度 (≥50μA) 导致电极距离200μm内的空间和时间神经血管脱.
- 延迟发病时间和减少血液流量的增加被观察到与高ICMS强度.
- 这些干扰归因于延迟的Ca2+信号传递和VMC中的Ca2+敏感性降低.
结论:
- ICMS的强度极大地影响了NVC.
- 低ICMS强度可以保持NVC,支持最佳的神经修复功能.
- 高强度的ICMS会破坏NVC,可能导致血液供应缺陷并损害神经修复器的有效性.
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