加快获得儿科药物的机会:从全球儿科配方加速器中吸取的经验教训,这是由世卫组织主办的网络
Martina Penazzato1, Asma Hafiz1, Sébastien Morin2
1Research for Health Department, Science Division, WHO, Geneva, Switzerland.
The Lancet. Child & adolescent health
|April 17, 2025
概括
全球儿科配方加速器 (GAP-f) 通过促进创新和合作,改善了儿童药物获取. 关键的学习重点是调整策略,利用平台试验,并确保政治意愿公平分配儿科配方.
科学领域:
- 全球健康 全球健康
- 儿科药理学 儿科药理学
- 药物 获取 获取 获取
背景情况:
- 减少新生儿和儿童死亡率的努力正在进行中,但公平获得适合年龄的药物仍然是一个重大挑战,特别是在低收入和中等收入国家.
- 全球儿科配方加速器 (GAP-f) 成立于2020年,是一个由世卫组织主办的网络,由33个合作伙伴组成,致力于加强创新和获得儿童友好的药物.
研究的目的:
- 概述GAP-f第二阶段 (2022-24) 的重点和经验教训,重点关注与利益相关者努力不一致的治疗领域.
- 确定改善儿科配方开发和获取的关键策略,包括临床试验方法,监管参与,新型交付技术和产品推出合作.
主要方法:
- 审查GAP-f的第二阶段活动,重点关注利益相关者协调,临床试验创新,监管参与,技术识别和协作产品推出.
- 对学习的分析,以告知未来的优先级,平台试验实施,激励儿童配方开发,以及有效向儿童提供药物的战略.
主要成果:
- 可适应的优先级制定流程和基于未满足需求的高影响力领域的重点是至关重要的.
- 平台试验有望加速证据生成,但需要监管指导,行业协作和克服运营/融资障碍.
- 激励针对小市场的儿科配方开发,并主动将创新与儿童需求相匹配是必不可少的.
结论:
- 成功的儿科医学发展需要政治意愿和社区参与,以创造需求,推广支持和公平使用.
- 专门的资金和有针对性的计划对于推动儿童医疗获取系统和可持续改进至关重要.
- 来自GAP-f实施的经验教训将指导未来的努力,以加快为儿童提供基本药物的进展.
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