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近期生物测试的进展,用于评估环境污染物的毒性,以影响为导向的分析

Yao Liu¹, Minjie Li², Qi-Lin Wan²

¹College of Life Sciences, China Jiliang University, Hangzhou 310018, China; Institute of Environmental and Health Sciences, China Jiliang University, Hangzhou 310018, China.

Journal of environmental sciences (China)

|April 17, 2025

概括

以效果为导向的分析 (EDA) 使用生物测试识别有毒环境混合物. 本综述涵盖了127项研究 (2014-2023年),详细介绍了生物测试,生物效应以及生态系统和人类健康保护的已识别污染物.

科学领域:

环境化学环境化学
生态毒理学生态毒理学
生物分析化学生物分析化学

背景情况:

环境化学混合物对生态系统和人类健康构成风险,即使度低.
以效果为导向的分析 (EDA) 对于识别这些复杂混合物中的关键毒素至关重要.
选择适当的生物测试对于在现实环境样本分析中成功进行EDA至关重要.

研究的目的:

审查从2014年到2023年应用EDA的研究.
总结EDA中使用的生物测试及其相关的生物效应.
根据其作用模式 (MOA) 讨论已识别的物质,并概述EDA的未来战略.

主要方法:

在环境样本上使用EDA的研究的系统文献综述.
从591个出版物 (2014-2023) 中选择了127项研究.
基于测量的终点进行生物试验的分类:受体介导的MOA,外来生物代谢和应激反应途径 (体外/体内).

主要成果:

127项研究使用EDA评估废水,地表水和沉积物的毒性影响.
通常使用的生物测试包括测量特定的MOA,外来生物代谢和应激反应.
与其MOA相关的已识别物质进行了讨论,强调了EDA的实用性.

结论:

使用生物分析方法检测环境污染物的EDA是一种强大的方法.
该审查概述了实际EDA应用的好处和局限性.
建议推进EDA的战略,以改善环境监测和风险评估.

关键词:

生物分析方法生物分析方法化学混合物是一种化学混合物.基于效果的方法基于效果的方法.主要的有毒物质是关键的有毒物质.水污染物水污染物

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