金属与糖尿病有关:来自全国跨部门调查的见解
Yang Zhou1, Long Zhang1, Tong Zheng1
1State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510655, China.
混合重金属暴露,包括,和,与中国农村地区糖尿病风险增加有关. 身体质量指数 (BMI) 在这些复杂的关系中起着调解作用.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 糖尿病和禁食葡萄糖 (IFG) 损害是全球主要的健康问题.
- 结合重金属暴露对糖尿病风险的影响尚不清楚.
- 农村人口可能面临独特的环境暴露.
研究的目的:
- 调查混合重金属暴露与糖尿病/IFG风险之间的关联.
- 探索身体质量指数 (BMI) 在这些协会中的调解作用.
- 分析不同金属之间与糖尿病风险相关的相互作用.
主要方法:
- 对中国农村2313名成年人的横截面研究.
- 使用ICP-MS.用尿中的 (Zn), (Cr), (Ni), (Cd) 和 (Pb) 的量化.
- 后勤回归和贝叶斯内核机器回归 (BKMR) 用于关联和相互作用分析.
- 调解分析以评估BMI的作用.
主要成果:
- 在尿中发现Zn,Cr和Ni与糖尿病风险增加之间存在显著的关联.
- 暴露增强了Zn和Cr对糖尿病/IFG风险的影响.
- 体重指数调解了Cr/Cd暴露与糖尿病风险之间的关系.
结论:
- 混合重金属暴露,特别是Zn,Cr和Ni,与更高的糖尿病风险有关.
- 体重指数 (BMI) 在金属诱导糖尿病中起着复杂的调解作用.
- 需要进一步的研究来阐明这些环境代谢相互作用背后的机制.
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