在急性冠状动脉综合征患者的血清肝胆系统功能的生物标志物与per-和多醇基物质之间的关联
Fang Xiao1, Ming Yang2, Junli Lv1
1Department of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang 050017, China.
Journal of environmental sciences (China)
|April 17, 2025
概括
这项研究发现,在急性冠状动脉综合征 (ACS) 患者中,和多醇基物质 (PFAS) 暴露与肝功能生物标志物之间存在关联. 具体来说,PFHxS暴露与较低的总胆汁酸 (TBA) 有关.
科学领域:
- 环境健康 环境健康
- 心血管医学 心血管医学
- 毒理学 毒理学 毒理学
背景情况:
- 肝胆系统功能异常与急性冠状动脉综合征 (ACS) 的预后不佳有关.
- 和多醇基物质 (PFAS) 暴露可能会影响肝胆功能,但对ACS患者的证据有限.
研究的目的:
- 调查血PFAS暴露与ACS患者肝胆系统功能生物标志物之间的关联.
主要方法:
- 利用了546名新诊断的ACS患者的数据.
- 评估了15种肝胆系统功能生物标志物.
- 采用多重线性回归,受限立方线 (RCS) 模型,以及对PFAS关联和混合物效应的量子g计算.
主要成果:
- 总胆汁酸 (TBA) 与 perfluorohexane sulfonic acid (PFHxS) 暴露有显著的负相关性.
- 在TBA和PFHxS之间观察到线性关联.
- 前专辑蛋白 (PA) 与PFAS原体和混合物有关.
结论:
- 提供了流行病学证据,将PFAS暴露 (单独的原体和混合物) 与ACS患者的血清肝胆功能生物标志物联系起来.
- 这些发现可能会为未来关于PFAS和心血管健康的机制研究提供信息.
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