将挥发性有机化合物暴露与骨质疏松风险通过基于不良结果途径方法论的氧化应激联系起来
Haolong Zhou1, Zhangbo Cui1, Dongsheng Di2
1Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Journal of environmental sciences (China)
|April 17, 2025
概括
暴露于挥发性有机化合物 (VOC) 与美国成年人骨质疏松症风险增加有关. 氧化应激,驱动interleukin-6,似乎是一个关键的机制连接VOCs和骨密度下降.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 据怀疑,暴露于挥发性有机化合物 (VOC) 会增加骨质疏松症 (OP) 风险,但机制尚不清楚.
- 不良结果路径 (AOP) 分析提供了一个研究这些机制联系的框架.
- 了解这些途径对于公共卫生至关重要,特别是对于中老年人群.
研究的目的:
- 使用AOP分析,探索VOC暴露和骨质疏松风险之间的潜在机制路径.
- 检查美国成年人中VOC代谢物 (VOCMs) 和OP相关表型之间的关联.
- 为未来关于VOC和骨健康的研究提供理论基础.
主要方法:
- 利用来自美国中老年 (≥40岁) 美国健康和营养检查调查 (NHANES) 的数据.
- 采用多变量调整的一般线性和加权定量和值模型来评估尿路VOCM和OP表型之间的关联.
- 开发了一个AOP框架,使用网络分析来识别目标基因和表型,包括氧化应激 (OS).
主要成果:
- 尿液中特定VOCM (3-和4-甲基希普酸,BPMA,N-乙-S-(3-基) -l-氨酸) 的含量增加与骨质疏松症的更高几率有关.
- 一种VOC混合物与OP几率的显著增加有关.
- AOP分析强调氧化应激作为一个关键的调解者,其中介质素-6被确定为潜在的分子启动事件.
结论:
- 特定的VOC暴露与美国成年人骨质疏松症风险增加和骨矿物质密度 (BMD) 改变有关.
- 氧化应激,可能由中白素-6启动,是一个合理的机制,将VOC暴露与骨质疏松症联系起来.
- 该研究提供了一个框架和证据,支持VOCs在骨健康中的作用,需要进一步调查.
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