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Updated: May 11, 2025

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过度表达T-bet增强了CAR T细胞效应器功能和抗原敏感性

Jennifer M Cimons1, Kole R DeGolier1, Samuel D Burciaga1

  • 1Pediatrics Hematolgy/Oncology/Bone Marrow Transplant, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, USA.

Journal for immunotherapy of cancer
|April 17, 2025
PubMed
概括

在CAR T细胞中过度表达T-bet可增强它们对抗癌症的能力,特别是当抗原低时. 这种方法可以改善T细胞的功能和持续性,而不会影响长期的有效性.

关键词:
收养细胞疗法 - ACT化学抗原受体 - - CAR

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