在经过甲状腺切除术的患者中减少术后语音变化的术后甲状腺松药的有效性:系统性审查和元分析
Dalia Hamdan1, Renad Alsolamy2, Atheer Altalhi3
1Otolaryngology-Head and Neck Surgery, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia.
Journal of voice : official journal of the Voice Foundation
|April 17, 2025
概括
术后的德克萨米他显著降低了甲状腺切除术后的立即语音变化,改善了患者报告的结果. 然而,没有观察到客观的声音改善,效果在一周内减弱.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 内分泌学 在内分泌学.
- 手术并发症 手术并发症
背景情况:
- 甲状腺切除术经常导致术后的声音变化,影响患者的生活质量.
- 术后的德克萨米他是一种潜在的干预措施,可以减少炎症和,从而减轻语音变化.
- 目前关于德克萨米他治疗甲状腺切除术后声音变化的有效性的证据是不确定的.
研究的目的:
- 系统地审查和对随机对照试验进行元分析,评估外科手术期间使用德克萨米他来减少甲状腺切除术后的语音变化.
- 评估主观和客观的语音结果.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 在MEDLINE,Cochrane和EMBASE数据库中进行搜索 (2022年9月).
- 包括8个随机对照试验,共有1244名参与者.
主要成果:
- 德克萨米他在甲状腺切除术后48小时内显著降低了主观语音功能障碍得分 (SMD: -0.55,P < 0.001).
- 在7天后,主观结果没有显著差异.
- 来自两个试验 (n=639) 的客观语音频率分析显示没有显著改善 (MD: 11.18,P = 0.44).
结论:
- 在甲状腺切除术后的立即时期,外科术期间的德克萨米有效地减少了主观语音功能障碍.
- 没有显著的客观声音改进被证明.
- 德克萨米他对语音质量的有益影响似乎是短暂的,在7天后减弱.
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