女性和男性的他类药物治疗的升级:基于人口的队列研究
Pauline Kiss1, Alicia Uijl1,2,3, Diederick E Grobbee1
1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
European heart journal. Quality of care & clinical outcomes
|April 17, 2025
概括
与男性相比,女性接受的他类药物治疗密集度较低,她们达到胆固醇目标的可能性也较低. 这突显了心血管疾病管理中的潜在基于性别的差异,影响了治疗的有效性.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 类药物对于预防和治疗心血管疾病至关重要.
- 现有证据表明,女性不太可能获得最佳的他类药物剂量并达到脂质目标.
- 了解他类药物定位的性别差异对于公平的心血管疾病护理至关重要.
研究的目的:
- 为了调查基于性别的差异在他类药物治疗定位模式.
- 评估男性和女性在达到胆固醇目标水平方面的差异.
- 分析荷兰医疗保健环境中的这些差异.
主要方法:
- 来自PHARMO数据网络 (2011-2020) 的他类药物发行数据的回顾性分析.
- 包括新的他类药物使用者,至少有两次记录的分发.
- 使用考克斯的比例危险模型进行升位分析和Poisson回归来实现胆固醇目标.
主要成果:
- 确定了68,150名新的他类药物使用者 (46%是女性);中位数年龄为65岁.
- 与男性相比,女性升位他类药物治疗的可能性比男性低28% (aHR 0.72).
- 妇女在六个月 (aRR 0.95) 和十八个月 (aRR 0.98) 达到胆固醇目标的可能性降低.
结论:
- 开始接受他类药物治疗的女性比男性更不太可能接受剂量定位.
- 女人也不太可能达到推的胆固醇目标水平.
- 这些发现表明,在心脏病治疗中使用他类药物时,可能存在基于性别的不平等现象.
相关概念视频
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
465
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
465
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
388
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
388
01:12Analysis of Population Pharmacokinetic Data
195
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
195
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
99
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
99